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Showing 1–6 of 6 results
Advanced filters: Author: Gunnar Sigurðsson Clear advanced filters

  • Mark McCarthy, Michael Boehnke, Andrew Morris and colleagues perform large-scale association analyses using the Metabochip to gain insights into the genetic architecture of type 2 diabetes. They report several new susceptibility loci, including two that show sex-differentiated effects on disease risk.

    • Andrew P Morris
    • Benjamin F Voight
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 44, P: 981-990

  • Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

    • Anubha Mahajan
    • Min Jin Go
    • Andrew P Morris
    Research
    Nature Genetics
    Volume: 46, P: 234-244

  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

    • Josée Dupuis
    • Claudia Langenberg
    • Inês Barroso
    Research
    Nature Genetics
    Volume: 42, P: 105-116

  • Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine mapping and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants is enriched for overlap with FOXA2 binding sites in human islet and liver cells, and they show that a likely causal variant near MTNR1B increases FOXA2-bound enhancer activity, providing a molecular mechanism to explain the effect of this locus on disease risk.

    • Kyle J Gaulton
    • Teresa Ferreira
    • Andrew P Morris
    Research
    Nature Genetics
    Volume: 47, P: 1415-1425