Nature Search

Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort

Shizhen He
Baninia Habchi
Susanna Klevebro
ResearchOpen Access03 Oct 2025
Journal of Exposure Science & Environmental Epidemiology

P: 1-16
Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Ambient air pollution exposure in early childhood has been linked to infection risk but the mechanism is unclear. Here, the authors investigate the association between air pollution-linked proteomic profiles in pregnancy and infection in early childhood using data from Denmark and Sweden.

Nicklas Brustad
Tingting Wang
Bo Chawes
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-10
Genome-wide association analysis identifies six new loci associated with forced vital capacity

Stephanie London, Martin Tobin and colleagues report meta-analyses of genome-wide association studies for forced vital capacity (FVC), a spirometric measure of pulmonary function that reflects lung volume. They identify six regions newly associated with FVC and demonstrate that candidate genes at these loci are expressed in lung tissue and primary lung cells.

Daan W Loth
María Soler Artigas
Stephanie J London
Research15 Jun 2014
Nature Genetics

Volume: 46, P: 669-677
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function.

María Soler Artigas
Louise V. Wain
Martin D. Tobin
ResearchOpen Access04 Dec 2015
Nature Communications

Volume: 6, P: 1-12
Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Anders Kämpe
Sanna Gudmundsson
Tuuli Lappalainen
Correspondence04 Apr 2025
Nature Medicine

Volume: 31, P: 1730-1732
Distinction between rhinitis alone and rhinitis with asthma using interactomics

Daniel Aguilar
Nathanaël Lemonnier
Jean Bousquet
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Ashley Budu-Aggrey
Anna Kilanowski
Lavinia Paternoster
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.

Leanne K. Küpers
Claire Monnereau
Janine F. Felix
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-11
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

The authors perform meta-analysis of GWAS studies for asthma from multiancestral cohorts. They identify five new loci and find that the asthma-associated loci are enriched near enhancer marks in immune cells.

Florence Demenais
Patricia Margaritte-Jeannin
Dan L. Nicolae
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 42-53
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.

Josine L. Min
Gibran Hemani
Caroline L. Relton
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1311-1321
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report the results of a large, multi-ancestry genome-wide association study of atopic dermatitis. They identify ten new susceptibility loci harboring candidate genes involved in innate host defense and T cell function.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research19 Oct 2015
Nature Genetics

Volume: 47, P: 1449-1456
Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Johannes Waage
Marie Standl
Klaus Bønnelykke
Amendments and Corrections16 Aug 2018
Nature Genetics

Volume: 50, P: 1343
Meta-analysis identifies seven susceptibility loci involved in the atopic march

The development of asthma following eczema is known as the atopic march. Here the authors conduct a GWAS on affected children and identify two novel loci associated with the disease phenotype.

Ingo Marenholz
Jorge Esparza-Gordillo
Young Ae Lee
ResearchOpen Access06 Nov 2015
Nature Communications

Volume: 6, P: 1-8
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Genome-wide association analyses identify new risk loci for allergic rhinitis and for sensitization to inhalant allergens. The associated regions implicate immune-related pathways, including innate and adaptive IgE-related mechanisms.

Johannes Waage
Marie Standl
Klaus Bønnelykke
Research16 Jul 2018
Nature Genetics

Volume: 50, P: 1072-1080
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report a meta-analysis of genome-wide association studies of atopic dermatitis. They report three newly identified associated loci near OVOL1 and ACTL9 and in KIF3A.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research25 Dec 2011
Nature Genetics

Volume: 44, P: 187-192
Allergic rhinitis

This Primer by Bousquet and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of allergic rhinitis. In addition, it reviews the quality-of-life issues faced by patients and provides an overview of how mobile health technologies could improve patient care.

Jean Bousquet
Josep M. Anto
Sanna Toppila-Salmi
Reviews03 Dec 2020
Nature Reviews Disease Primers

Volume: 6, P: 1-17
Post COVID-19 symptoms are common, also among young adults in the general population

Ida Mogensen
Sandra Ekström
Inger Kull
ResearchOpen Access12 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Inflammation-related plasma protein levels and association with adiposity measurements in young adults

Susanna Klevebro
Sophia Björkander
Erik Melén
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-11
Hypomethylation of HOXA4 promoter is common in Silver-Russell syndrome and growth restriction and associates with stature in healthy children

Mari Muurinen
Katariina Hannula-Jouppi
Juha Kere
ResearchOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1-11

Search

Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort

Air pollution-induced proteomic alterations increase the risk of child respiratory infections

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Distinction between rhinitis alone and rhinitis with asthma using interactomics

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Allergic rhinitis

Post COVID-19 symptoms are common, also among young adults in the general population

Inflammation-related plasma protein levels and association with adiposity measurements in young adults

Hypomethylation of HOXA4 promoter is common in Silver-Russell syndrome and growth restriction and associates with stature in healthy children

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