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Showing 1–4 of 4 results
Advanced filters: Author: Eeva Korpi-Hyövälti Clear advanced filters

  • Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

    • Anubha Mahajan
    • Min Jin Go
    • Andrew P Morris
    Research
    Nature Genetics
    Volume: 46, P: 234-244

  • Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their analyses provide insights into the pathophysiology of hypertension and highlight new potential targets for clinical intervention.

    • Praveen Surendran
    • Fotios Drenos
    • Patricia B Munroe
    Research
    Nature Genetics
    Volume: 48, P: 1151-1161

  • Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine mapping and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants is enriched for overlap with FOXA2 binding sites in human islet and liver cells, and they show that a likely causal variant near MTNR1B increases FOXA2-bound enhancer activity, providing a molecular mechanism to explain the effect of this locus on disease risk.

    • Kyle J Gaulton
    • Teresa Ferreira
    • Andrew P Morris
    Research
    Nature Genetics
    Volume: 47, P: 1415-1425

  • Mark McCarthy, Michael Boehnke, Andrew Morris and colleagues perform large-scale association analyses using the Metabochip to gain insights into the genetic architecture of type 2 diabetes. They report several new susceptibility loci, including two that show sex-differentiated effects on disease risk.

    • Andrew P Morris
    • Benjamin F Voight
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 44, P: 981-990