Nature Search

Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immunity

McKenna D. Roe
Si’Ana A. Coggins
Eric D. Laing
ResearchOpen Access29 Oct 2025
npj Viruses

Volume: 3, P: 1-5
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
A quantitative high-throughput screening pipeline to identify small molecule inhibitors of Chikungunya nsP2 protease

Shuaizhang Li
Xin Hu
Natalia J. Martinez
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Mutations in RAS and PI3Kα drive cancer by activating the PI3K-AKT-mTOR pathway. The authors present RAS-PI3Kα structures, revealing interaction interfaces, isoform-specific differences, and a framework for designing PI3Kα-specific inhibitors.

Daniel Czyzyk
Wupeng Yan
Dhirendra K. Simanshu
ResearchOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1-19
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

There is lack of therapies targeting the PAX3-FOXO1 fusion oncogene in fusion-positive rhabdomyosarcoma (FP-RMS). Here, the authors identify and characterise an inhibitor with highest inhibition of histone lysine demethylase 3B that suppresses PAX3-FOXO1 activity in FP-RMS.

Yong Yean Kim
Berkley E. Gryder
Javed Khan
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.

Ved P. Sharma
Binwu Tang
Maja H. Oktay
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-24
Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling

Understanding the infection parameters and host responses against SARS-CoV-2 require data from large cohorts using standardized methods. Here, the authors optimize a serum ELISA protocol that has minimal cross-reactivity and flexible sample collection workflow in an attempt to standardize data generation and help inform on COVID-19 pandemic and immunity.

Carleen Klumpp-Thomas
Heather Kalish
Kaitlyn Sadtler
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

The high-resolution crystal structure of the SHOC2–MRAS–PP1C complex provides insights into the complex assembly, RAF dephosphorylation, MRAS selectivity versus canonical RAS isoforms, and the impact of Noonan syndrome mutations on complex formation.

Daniel A. Bonsor
Patrick Alexander
Dhirendra K. Simanshu
Research29 Sept 2022
Nature Structural & Molecular Biology

Volume: 29, P: 966-977
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and propose a model of the membrane-bound RAS-RAF complex.

Timothy H. Tran
Albert H. Chan
Dhirendra K. Simanshu
ResearchOpen Access19 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Potent ferroptosis agent RSL3 induces cleavage of Pyroptosis-Specific gasdermins in Cancer cells

William G. Herrick
Huong-Lan Tran
Apurva K. Srivastava
ResearchOpen Access12 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Diffuse X-ray emission around an ultraluminous X-ray pulsar

Diffuse X-ray emission is detected around an ultraluminous X-ray source, interpreted as a wind-powered expanding nebula. Its energetics suggests that a super-Eddington regime can be longer than the spin-up time of the central neutron star.

Andrea Belfiore
Paolo Esposito
Luca Zampieri
Research28 Oct 2019
Nature Astronomy

Volume: 4, P: 147-152
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

Sarah D. Cramer
Julie A. Hixon
Scott K. Durum
Research15 Feb 2018
Leukemia

Volume: 32, P: 1795-1882
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements

Structural analysis and molecular dynamics of the RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric binding of RAF1 to HSP90, a bridging role for CDC37, HSP90’s structural rearrangements, and interactions of HSP90 with unfolded regions of RAF1.

Lorenzo I. Finci
Mayukh Chakrabarti
Dhirendra K. Simanshu
ResearchOpen Access02 Mar 2024
Communications Biology

Volume: 7, P: 1-18
Reduced dynamic complexity allows structure elucidation of an excited state of KRAS^G13D

Structural analysis reveals an intermediate (excited) state of GMPPNP-bound KRAS^G13D which includes the formation of a new pocket in the allosteric lobe that could be exploited for developing new therapeutics against KRAS^G13D-driven cancers.

Fa-An Chao
Albert H. Chan
Gabriel Cornilescu
ResearchOpen Access02 Jun 2023
Communications Biology

Volume: 6, P: 1-12
mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants

Yunkai Yu
Dominic Esposito
Liang Cao
ResearchOpen Access16 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

Srisathiyanarayanan Dharmaiah
Timothy H. Tran
Dhirendra K. Simanshu
ResearchOpen Access19 Jul 2019
Scientific Reports

Volume: 9, P: 1-15
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

William K. Gillette
Dominic Esposito
Andrew G. Stephen
ResearchOpen Access02 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

Ren-Yuan Bai
Dominic Esposito
Verena Staedtke
Research24 May 2019
Gene Therapy

Volume: 26, P: 277-286
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immunity

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

A quantitative high-throughput screening pipeline to identify small molecule inhibitors of Chikungunya nsP2 protease

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma

Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Potent ferroptosis agent RSL3 induces cleavage of Pyroptosis-Specific gasdermins in Cancer cells

Diffuse X-ray emission around an ultraluminous X-ray pulsar

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS^G13D

mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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