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Showing 1–18 of 18 results
Advanced filters: Author: Csaba P. Kovesdy Clear advanced filters

  • Hyperkalaemia is common in patients with chronic kidney disease and is associated with adverse outcomes. Here, Csaba Kovesdy gives an overview of the mechanisms underlying hyperkalaemia and its clinical consequences in this patient population, and discusses current treatment regimens, as well as emerging therapies that might enable the more-liberal use of beneficial therapeutics in specific populations of patients at risk of hyperkalaemia.

    • Csaba P. Kovesdy
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 653-662

  • Preliminary findings suggest that oral sodium bicarbonate administration could become a major addition to the armamentarium of renoprotective measures for individuals with chronic kidney disease.

    • Csaba P. Kovesdy
    • Kamyar Kalantar-Zadeh
    News & Views
    Nature Reviews Nephrology
    Volume: 6, P: 15-17

  • Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

    • Praveen Surendran
    • Elena V. Feofanova
    • Joanna M. M. Howson
    Research
    Nature Genetics
    Volume: 52, P: 1314-1332

  • Protein-energy wasting (PEW), manifested by low serum levels of albumin and weight loss, is common in patients with chronic kidney disease (CKD) and is a strong predictor of mortality. The authors of this Review discuss the evidence indicating that dietary interventions and nutritional support can mitigate PEW and improve outcomes in patients with CKD. They also describe how in-center meals and oral supplements during dialysis may improve survival and quality of life in this group of patients.

    • Kamyar Kalantar-Zadeh
    • Noël J. Cano
    • T. Alp Ikizler
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 369-384

  • In the USA, mortality among patients with chronic kidney disease (CKD) and end-stage renal disease has declined over the past two decades. By contrast, new data indicate that the rate of CKD-associated deaths is increasing worldwide. This important finding highlights CKD as a major contributor to global morbidity and mortality.

    • Connie M. Rhee
    • Csaba P. Kovesdy
    News & Views
    Nature Reviews Nephrology
    Volume: 11, P: 199-200

  • Although cardiovascular disease is the most common cause of death among people with chronic renal dysfunction, conventional cardiovascular risk factors are paradoxically associated with improved survival in hemodialysis populations. Here, the authors analyze emerging data that support this 'reverse epidemiology'. Confirmation of this phenomenon might lead to the formulation of more effective management strategies, tailored to patient characteristics and disease stage.

    • Kamyar Kalantar-Zadeh
    • Csaba P Kovesdy
    • Gregg C Fonarow
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 3, P: 493-506

  • In this Review, the authors describe the potential benefits of partial versus radical nephrectomy for small renal cell carcinomas. They also discuss the risk ofde novokidney disease or progression of pre-existing chronic kidney disease after nephrectomy, the potential factors that might influence patient prognosis after this surgery, and the need for further research in this field.

    • Lin Li
    • Wei Ling Lau
    • Kamyar Kalantar-Zadeh
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 135-145

  • Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.

    • Ayush Giri
    • Jacklyn N. Hellwege
    • Todd L. Edwards
    Research
    Nature Genetics
    Volume: 51, P: 51-62

  • Early initiation of dialysis has been recommended by guidelines over the past two decades, but recent studies and a randomized, controlled trial indicate that patients who start dialysis early might in fact have worse outcomes. The authors of this Review discuss studies of early and late dialysis initiation and highlight factors that influence the association between dialysis initiation and outcomes in transplant-naive patients with chronic kidney disease and in patients with a failed allograft.

    • Miklos Z. Molnar
    • Akinlolu O. Ojo
    • Kamyar Kalantar-Zadeh
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 284-292

  • Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.

    • Jacklyn N. Hellwege
    • Digna R. Velez Edwards
    • Adriana M. Hung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Heart failure and renal dysfunction frequently coexist. The term cardiorenal syndrome (CRS) is frequently used to describe this scenario, but the definition of CRS has been a matter of debate and has evolved over time. Here, the authors review the concept of CRS and its evolution and classification, and describe current and future targets for the clinical management of CRS. In addition, they propose a new classification system with seven distinct categories.

    • Parta Hatamizadeh
    • Gregg C. Fonarow
    • Kamyar Kalantar-Zadeh
    Reviews
    Nature Reviews Nephrology
    Volume: 9, P: 99-111