Nature Search

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Albert Henry
Xiaodong Mo
R. Thomas Lumbers
ResearchOpen Access04 Mar 2025
Nature Genetics

Volume: 57, P: 815-828
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

Genome-wide association analyses identify risk loci for spontaneous coronary artery dissection and implicate arterial integrity and tissue-mediated coagulation in the disease etiology. Several risk variants show opposite effects on coronary artery disease risk.

David Adlam
Takiy-Eddine Berrandou
Nabila Bouatia-Naji
ResearchOpen Access29 May 2023
Nature Genetics

Volume: 55, P: 964-972
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study

CETP inhibitors are being developed for treatment of coronary heart disease. Here, the authors show that the anticipated beneficial effects of lower plasma levels of CETP are shared among individuals of European and East Asian ancestry.

Diana Dunca
Sandesh Chopade
Amand F. Schmidt
ResearchOpen Access21 Jun 2024
Nature Communications

Volume: 15, P: 1-10
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

Sean L. Zheng
Albert Henry
R. Thomas Lumbers
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2646-2658
Genetic architecture of host proteins involved in SARS-CoV-2 infection

Finding effective treatments for COVID-19 depends upon understanding genetic regulation of proteins involved in SARS-CoV-2 infection and host response. Here, the authors identify genetic variants linked to expression of such proteins, data which could lead to the discovery of therapeutic targets.

Maik Pietzner
Eleanor Wheeler
Claudia Langenberg
ResearchOpen Access16 Dec 2020
Nature Communications

Volume: 11, P: 1-14
Genetic drug target validation using Mendelian randomisation

Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.

Amand F. Schmidt
Chris Finan
Aroon D. Hingorani
ResearchOpen Access26 Jun 2020
Nature Communications

Volume: 11, P: 1-12
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.

Nora Franceschini
Claudia Giambartolomei
Christopher J. O’Donnell
ResearchOpen Access03 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease

Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that previous failure of CETP inhibitors are likely compound and not drug target-related.

Amand F. Schmidt
Nicholas B. Hunt
Chris Finan
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-10
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

Drug target Mendelian randomization (MR) uses genetic variation in or near a gene encoding a drug target to anticipate the effect of drug action on the same target. Using drug target MR, the authors prioritized 30 targets that might elicit beneficial effects in the prevention or treatment of coronary heart disease.

María Gordillo-Marañón
Magdalena Zwierzyna
Chris Finan
ResearchOpen Access21 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

Lucy J. Goudswaard
Madeleine L. Smith
Laura J. Corbin
ResearchOpen Access29 Nov 2023
Scientific Reports

Volume: 13, P: 1-15
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Multi-ancestry genome-wide association meta-analysis identifies new risk loci for CAC. Functional evidence implicates candidate causal genes as regulators of smooth muscle cell-mediated calcification.

Maryam Kavousi
Maxime M. Bos
Clint L. Miller
Research28 Sept 2023
Nature Genetics

Volume: 55, P: 1651-1664
Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome.

Catherine S. Storm
Demis A. Kia
Nicholas W. Wood
ResearchOpen Access20 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Disease coverage of human genome-wide association studies and pharmaceutical research and development

Gordillo-Marañón et al. identify areas of convergence or divergence between genome-wide association studies (GWAS) and pharmaceutical research and development. They provide target-disease indication lists to prioritize drug development efforts in areas with genomic support, and diseases with few effective treatments that could benefit from GWAS.

María Gordillo-Marañón
Amand F. Schmidt
Chris Finan
ResearchOpen Access08 Oct 2024
Communications Medicine

Volume: 4, P: 1-11
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Sonia Shah
Albert Henry
R. Thomas Lumbers
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.

Yali Xue
Massimo Mezzavilla
Eleftheria Zeggini
ResearchOpen Access23 Jun 2017
Nature Communications

Volume: 8, P: 1-7
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Deregulated Wnt pathway activity has been implicated in many cancers, making this pathway an attractive target for anticancer therapies. Here, a small molecule inhibitor of the Wnt pathway is identified and its direct target and mechanism of action are characterized, providing new insights into the physiological regulation of the Wnt pathway and new possibilities for targeted Wnt pathway therapeutics.

Shih-Min A. Huang
Yuji M. Mishina
Feng Cong
Research16 Sept 2009
Nature

Volume: 461, P: 614-620
Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection

Maik Pietzner
Eleanor Wheeler
Claudia Langenberg
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Improving the odds of drug development success through human genomics: modelling study

Aroon D. Hingorani
Valerie Kuan
Juan Pablo Casas
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-25
Mendelian Randomisation study of the influence of eGFR on coronary heart disease

Pimphen Charoen
Dorothea Nitsch
Vincent Plagno
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes

Schmidt et al. evaluate the effects of elevated circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Effects are seen on measures of atherosclerosis, blood pressure, c-reactive protein, coronary heart disease, heart failure, Alzheimer’s disease, type 2 diabetes and inflammatory bowel disease.

Amand F. Schmidt
Roshni Joshi
Chris Finan
ResearchOpen Access20 Jan 2023
Communications Medicine

Volume: 3, P: 1-10
Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups

Tewodros Gebresilase
Chris Finan
Fasil Tekola-Ayele
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
Using ancestry-informative markers to identify fine structure across 15 populations of European origin

Laura M Huckins
Vesna Boraska
Ioanna Tachmazidou
ResearchOpen Access19 Feb 2014
European Journal of Human Genetics

Volume: 22, P: 1190-1200
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
Amendments and CorrectionsOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-4

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