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Showing 1–15 of 15 results
Advanced filters: Author: Cedric Feschotte Clear advanced filters

  • Commemorating the 40th anniversary of Barbara McClintock’s Nobel Prize in Physiology or Medicine for her discovery of transposable elements, Cédric Feschotte reflects on McClintock’s life and legacy and how her work has shaped and defined the field of genetics.

    • Cédric Feschotte
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 797-800

  • How did the complex regulatory networks that control eukaryotic gene expression evolve? This article explores evidence that transposable elements played an important part by providing thecis and transcomponents of these networks.

    • Cédric Feschotte
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 397-405

  • Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

    • DongAhn Yoo
    • Arang Rhie
    • Evan E. Eichler
    ResearchOpen Access
    Nature
    Volume: 641, P: 401-418

  • A survey of mammalian genomes has unexpectedly unearthed DNA derived from bornaviruses, leading to speculation about the role of these viruses in causing mutations with evolutionary and medical consequences.

    • Cédric Feschotte
    News & Views
    Nature
    Volume: 463, P: 39-40

  • A large array of viral sequences is being uncovered in eukaryotic genome sequences, revealing that almost any type of virus — not just retroviruses — can become part of host genomes. These discoveries provide new information about the origins and evolution of modern day viruses and host–virus relationships.

    • Cédric Feschotte
    • Clément Gilbert
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 283-296

  • Transposable elements (TEs) are widely known for their deleterious consequences of selfish propagation and mutagenesis. However, as described in this Review, TEs also provide hosts with rich, beneficial gene-regulatory machinery in the form of regulatory DNA elements and TE-derived gene products. The authors highlight the diverse regulatory contributions of TEs to organismal physiology and pathology, provide a framework for responsibly assigning functional roles to TEs and offer visions for the future.

    • Edward B. Chuong
    • Nels C. Elde
    • Cédric Feschotte
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 71-86

  • Half of our genome is transposable elements (TEs), often called junk DNA. Using the latest ENCODE data, the authors find TEs to contribute ~25% of human regulatory elements (REs). TEs can be adopted into new REs or replace old ones during evolution.

    • Alan Y. Du
    • Jason D. Chobirko
    • Ting Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Biomphalaria glabrata is a fresh water snail that acts as a host for trematode Schistosoma mansoni that causes intestinal infection in human. This work describes the genome and transcriptome analyses from 12 different tissues of B glabrata, and identify genes for snail behavior and evolution.

    • Coen M. Adema
    • LaDeana W. Hillier
    • Richard K. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • 'Horizontal gene transfer' refers to the passage of genetic material between non-mating species. Transposable elements (transposons) may be especially prone to horizontal gene transfer, but the mechanisms by which they can spread across diverged species have been elusive. Here it is shown that transposons can spread by hitchhiking in the genomes of parasites. The amount of DNA that can be transferred in this way underscores the impact of horizontal gene transfer on genome evolution.

    • Clément Gilbert
    • Sarah Schaack
    • Cédric Feschotte
    Research
    Nature
    Volume: 464, P: 1347-1350

  • Arc, a master regulator of synaptic plasticity, can mediate intercellular RNA transfer. Arc evolved from retrotransposon genes. Erlendsson et al. present structures of retroviral-like Arc capsids as a basis to understand their function.

    • Simon Erlendsson
    • Dustin R. Morado
    • John A. G. Briggs
    Research
    Nature Neuroscience
    Volume: 23, P: 172-175

  • The regulatory sequences carried by transposable elements (TEs) often recruit the transcription machinery and affect host gene expression. Recent studies have revealed mechanisms by which TEs contribute to transcription regulation, including donation of enhancer and promoter sequences, modification of 3D chromatin architecture, and generation of novel regulatory non-coding RNAs and transcription factors.

    • Raquel Fueyo
    • Julius Judd
    • Joanna Wysocka
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 481-497