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Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Infection with Omicron after vaccination produces cross-neutralizing antibodies to other variants of concern, whereas this induces a limited response to non-Omicron variants in unvaccinated individuals.

Rahul K. Suryawanshi
Irene P. Chen
Melanie Ott
ResearchOpen Access18 May 2022
Nature

Volume: 607, P: 351-355
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Camille R. Simoneau
Pei-Yi Chen
Melanie Ott
ResearchOpen Access04 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease.

Wilfredo F Garcia-Beltran
Angelique Hölzemer
Marcus Altfeld
Research25 Jul 2016
Nature Immunology

Volume: 17, P: 1067-1074
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
ARL13B controls male reproductive tract physiology through primary and Motile Cilia

The deletion of ARL13B disrupts primary and motile cilia structure in the efferent ductules, leading to impaired homeostasis, inflammation, and subfertility. This highlights ARL13B’s critical role in male reproductive physiology.

Céline Augière
Gabriel Campolina-Silva
Clémence Belleannée
ResearchOpen Access14 Oct 2024
Communications Biology

Volume: 7, P: 1-17

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Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

ARL13B controls male reproductive tract physiology through primary and Motile Cilia

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