Nature Search

Retraction Note: Pluripotency of mesenchymal stem cells derived from adult marrow

Yuehua Jiang
Balkrishna N. Jahagirdar
Catherine M. Verfaillie
Amendments and Corrections17 Jun 2024
Nature

Volume: 630, P: 1020
Integrated multimodal cell atlas of Alzheimer’s disease

The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

Mariano I. Gabitto
Kyle J. Travaglini
Ed S. Lein
ResearchOpen Access14 Oct 2024
Nature Neuroscience

Volume: 27, P: 2366-2383
Human neocortical expansion involves glutamatergic neuron diversification

Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

Jim Berg
Staci A. Sorensen
Ed S. Lein
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 151-158
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

Cyril Pottier
Fahri Küçükali
Rosa Rademakers
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Correction: Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Jieqi Wang
Jan Eike Wegener
Andrew A. Pieper
Amendments and Corrections15 Jul 2015
Nature

Volume: 525, P: 552
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Jim Berg
Staci A. Sorensen
Ed S. Lein
Amendments and CorrectionsOpen Access06 Jan 2022
Nature

Volume: 601, P: E12
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Jieqi Wang
Jan Eike Wegener
Andrew A. Pieper
Research20 May 2015
Nature

Volume: 521, P: E1-E4
Mapping human tissues with highly multiplexed RNA in situ hybridization

Application of multiplexed RNA in situ mapping techniques to human tissues remains challenging. Here, the authors report DART-FISH, a padlock probe-based technology capable of profiling large numbers of genes in centimetre-sized human tissue sections.

Kian Kalhor
Chien-Ju Chen
Kun Zhang
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Clonal hematopoiesis is associated with protection from Alzheimer’s disease

Clonal hematopoiesis of indeterminate potential (CHIP) was found to be associated with a protective effect from Alzheimer’s disease (AD) in large population-based cohorts.

Hind Bouzid
Julia A. Belk
Siddhartha Jaiswal
ResearchOpen Access15 Jun 2023
Nature Medicine

Volume: 29, P: 1662-1670
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

Here, the authors show that histone serine-ADP-ribosylation is decreased in Alzheimer’s disease brains and increased tyrosine levels deplete tyrosyl-tRNA synthetase levels and cause neuronal damage. Cis-resveratrol was shown to facilitate histone serine-ADP-ribosylation-dependent DNA repair and provides neuroprotection, while trans-resveratrol induces neurodegeneration in rat cortical neurons.

Megha Jhanji
Chintada Nageswara Rao
Mathew Sajish
ResearchOpen Access10 Jun 2022
Nature Communications

Volume: 13, P: 1-17
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Comparative cellular analysis of motor cortex in human, marmoset and mouse

An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

Trygve E. Bakken
Nikolas L. Jorstad
Ed S. Lein
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 111-119
Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease

Resilience to Alzheimer’s disease (RAD) is an uncommon combination of high disease burden without dementia. The authors perform proteomic analysis of RAD brains and show lower isocortical and hippocampal soluble Aβ levels, actin filament-based processes, cellular detoxification, and wound healing are significant features.

Zhi Huang
Gennifer E. Merrihew
Thomas J. Montine
ResearchOpen Access12 May 2023
Nature Communications

Volume: 14, P: 1-14
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Eric M. Reiman
Joseph F. Arboleda-Velasquez
Yi Zhao
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophysiological synaptic E/I ratio in the parietal cortex.

Julie C. Lauterborn
Pietro Scaduto
Agenor Limon
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-15
Conserved cell types with divergent features in human versus mouse cortex

RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

Rebecca D. Hodge
Trygve E. Bakken
Ed S. Lein
Research21 Aug 2019
Nature

Volume: 573, P: 61-68
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Erratum: Pluripotency of mesenchymal stem cells derived from adult marrow

Yuehua Jiang
Balkrishna N. Jahagirdar
Catherine M. Verfaillie
Amendments and Corrections14 Jun 2007
Nature

Volume: 447, P: 880-881
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

Yuehua Jiang
Balkrishna N. Jahagirdar
Catherine M. Verfaillie
Research20 Jun 2002
Nature

Volume: 418, P: 41-49
A multimodal cell census and atlas of the mammalian primary motor cortex

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Edward M. Callaway
Hong-Wei Dong
Susan Sunkin
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 86-102
Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression

An improved method for single-cell analysis of histone modifications is applied to stem cell differentiation and cancer.

Steven J. Wu
Scott N. Furlan
Anoop P. Patel
Research12 Apr 2021
Nature Biotechnology

Volume: 39, P: 819-824
SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) is a multifaceted open-data resource that is designed to identify cellular and molecular pathologies that underlie Alzheimer’s disease. Integrating neuropathology, single-cell and spatial genomics, and longitudinal clinical metadata, SEA-AD is a unique resource for studying the pathogenesis of Alzheimer’s disease and related dementias.

Michael Hawrylycz
Eitan S. Kaplan
Ed S. Lein
Comments & Opinion14 Oct 2024
Nature Aging

Volume: 4, P: 1331-1334
Dissecting the human leptomeninges at single-cell resolution

The meninges protect the central nervous system at the brain border, and its dysfunction can lead to neural inflammation and cell damage. Here, the authors uncover the gene signatures of diverse cell types in the aged human leptomeninges and highlight their changes in Alzheimer’s Disease.

Nicola A. Kearns
Artemis Iatrou
Yanling Wang
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-16
Author Correction: Comparative cellular analysis of motor cortex in human, marmoset and mouse

Trygve E. Bakken
Nikolas L. Jorstad
Ed S. Lein
Amendments and CorrectionsOpen Access22 Mar 2022
Nature

Volume: 604, P: E8
Human microglia show unique transcriptional changes in Alzheimer’s disease

Microglia, the innate immune cells of the brain, exhibit diverse functions and can influence Alzheimer’s disease progression. This study explores human microglial diversity in Alzheimer’s disease, uncovering unique disease-associated microglial populations and predicting underlying gene regulatory networks.

Katherine E. Prater
Kevin J. Green
Suman Jayadev
ResearchOpen Access29 May 2023
Nature Aging

Volume: 3, P: 894-907
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Luminex-based quantification of Alzheimer’s disease neuropathologic change in formalin-fixed post-mortem human brain tissue

C. Dirk Keene
Angela M. Wilson
Martin Darvas
Research20 Dec 2018
Laboratory Investigation

Volume: 99, P: 1056-1067
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
A single-cell based precision medicine approach using glioblastoma patient-specific models

James H. Park
Abdullah H. Feroze
Anoop P. Patel
ResearchOpen Access08 Aug 2022
npj Precision Oncology

Volume: 6, P: 1-13
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning

Andrew Tritt
John K. Yue
Ross Zafonte
ResearchOpen Access01 Dec 2023
Scientific Reports

Volume: 13, P: 1-16
Cross-species comparative analysis of single presynapses

Eloïse Berson
Chandresh R. Gajera
Thomas J. Montine
ResearchOpen Access24 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury

Aric F. Logsdon
Abigail G. Schindler
David G. Cook
ResearchOpen Access10 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Joshua C. Bis
Xueqiu Jian
Lindsay A. Farrer
ResearchOpen Access14 Aug 2018
Molecular Psychiatry

Volume: 25, P: 1859-1875
A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

Jonathan T. Ting
Brian Kalmbach
Ed Lein
ResearchOpen Access30 May 2018
Scientific Reports

Volume: 8, P: 1-13
Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling

Jing Shang
Pavel Zrazhevskiy
Xiaohu Gao
ResearchOpen Access02 Sept 2015
Scientific Reports

Volume: 5, P: 1-12
DNA methylation of TOMM40-APOE-APOC2 in Alzheimer’s disease

Yvonne Shao
McKenzie Shaw
Lynn M. Bekris
Research25 Jan 2018
Journal of Human Genetics

Volume: 63, P: 459-471
Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups

Shubhabrata Mukherjee
Jesse Mez
Paul K. Crane
ResearchOpen Access04 Dec 2018
Molecular Psychiatry

Volume: 25, P: 2942-2951
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury

Jacqueline R. Kulbe
Sonia Jain
Ross Zafonte
ResearchOpen Access18 Jun 2022
Neuropsychopharmacology

Volume: 47, P: 2300-2308
A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer’s disease

Gennifer E. Merrihew
Jea Park
Michael J. MacCoss
ResearchOpen Access14 Apr 2023
Scientific Data

Volume: 10, P: 1-13
Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer’s disease

Nadia O Postupna
C Dirk Keene
Martin Darvas
Research28 Jul 2014
Laboratory Investigation

Volume: 94, P: 1161-1172
Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice

Yue Yang
Macarena S Aloi
Thomas J Montine
Research08 Sept 2014
Laboratory Investigation

Volume: 94, P: 1224-1236
Correction: Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups

Shubhabrata Mukherjee
Jesse Mez
Paul K. Crane
Amendments and Corrections15 Jan 2019
Molecular Psychiatry

Volume: 25, P: 3100
Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury

Jacqueline R. Kulbe
Sonia Jain
Ross Zafonte
Amendments and CorrectionsOpen Access30 Sept 2022
Neuropsychopharmacology

Volume: 47, P: 2332

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