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Showing 1–2 of 2 results
Advanced filters: Author: Benjamin Götte Clear advanced filters
  • X-ray crystallography, cryo-electron microscopy, structural modelling, biochemistry, cell biology, and evolutionary analysis enable characterization of ORF2p, the reverse transcriptase of the ancient ‘parasitic’ LINE-1 retrotransposon that has written around one-third of the human genome.

    • Eric T. Baldwin
    • Trevor van Eeuwen
    • Martin S. Taylor
    ResearchOpen Access
    Nature
    Volume: 626, P: 194-206
  • Riplet conjugates K63-Ub chain to RIG-I in order to induce a robust antiviral response, but the mechanism of action remains unclear. Here, the authors show that Riplet recognizes RIG-I regardless of its RNA-bound status and promotes RIG-I signaling independent of RIG-I oligomerization.

    • Wenshuai Wang
    • Benjamin Götte
    • Anna Marie Pyle
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13