Nature Search

The impact of childhood asthma on daily life of the family-a qualitative study using recurrent thematic analysis

Barbara P. Yawn
Research01 Sept 2003
Primary Care Respiratory Journal

Volume: 12, P: 82-85
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally bioavailable and selective degrader of SMARCA2.

Christiane Kofink
Nicole Trainor
William Farnaby
ResearchOpen Access10 Oct 2022
Nature Communications

Volume: 13, P: 1-15
High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting

Immunomagnetic cell sorting implemented in a microfluidic chip can perform loss-of-function CRISPR–Cas9-mediated phenotypic screening at higher throughput than fluorescence-activated cell sorting.

Barbara Mair
Peter M. Aldridge
Shana O. Kelley
Research23 Sept 2019
Nature Biomedical Engineering

Volume: 3, P: 796-805
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
A cohesin traffic pattern genetically linked to gene regulation

The authors describe how three types of cis-element (CTCF sites, active TSSs and TTSs) regulate cohesin trafficking along chromosomes. They uncover that this cohesin traffic pattern is genetically linked to gene regulation and RNA processing.

Anne-Laure Valton
Sergey V. Venev
Job Dekker
Research08 Dec 2022
Nature Structural & Molecular Biology

Volume: 29, P: 1239-1251
Digital microfluidic isolation of single cells for -Omics

Multi-Omic approaches are a powerful way for obtaining in-depth understanding of a cell’s state. Here the authors present DISCO, combining digital microfluidics, laser cell lysis, and artificial intelligence-driven image processing to analyze single-cell genomes, transcriptomes and proteomes in a mixed population.

Julian Lamanna
Erica Y. Scott
Aaron R. Wheeler
ResearchOpen Access11 Nov 2020
Nature Communications

Volume: 11, P: 1-13
MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

Michal Smida
Ferran Fece de la Cruz
Sebastian M. B. Nijman
ResearchOpen Access06 Dec 2016
Nature Communications

Volume: 7, P: 1-13
CLP1 links tRNA metabolism to progressive motor-neuron loss

Inactivating the CLP1 RNA kinase in mice leads to a progressive loss of motor neurons, through a mechanism related to the accumulation of a novel set of small RNA fragments derived from aberrant processing of tyrosine pre-transfer RNA.

Toshikatsu Hanada
Stefan Weitzer
Josef M. Penninger
Research10 Mar 2013
Nature

Volume: 495, P: 474-480
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Enhanced ice sheet melting driven by volcanic eruptions during the last deglaciation

The impact of volcanism on ice sheet melting during the last deglaciation is poorly understood and limited by a lack of suitable proxies. Here, the authors combine annually resolved records of ice sheet melting with numerical models to show that ice sheets are sensitive to high-latitude volcanic eruptions.

Francesco Muschitiello
Francesco S. R. Pausata
Barbara Wohlfarth
ResearchOpen Access24 Oct 2017
Nature Communications

Volume: 8, P: 1-9
NEONATAL CARDIOVASCULAR EFFECTS OF VERAPAMIL

Norman Gootman
Barbara J Buckley
Barbara J Peterson
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 122
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
The Effects of an Alpha-2 Adrenergic Agonist, Guanfacine, on rCBF in Human Cortex in Normal Controls and Subjects with Focal Epilepsy

Barbara E Swartz
Edward Kovalik
Mark A Mandelkern
Research01 Sept 2000
Neuropsychopharmacology

Volume: 23, P: 263-275
An observational analysis of frailty in combination with loneliness or social isolation and their association with socioeconomic deprivation, hospitalisation and mortality among UK Biobank participants

Marina Politis
Lynsay Crawford
Peter Hanlon
ResearchOpen Access27 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
An analysis of frailty and multimorbidity in 20,566 UK Biobank participants with type 2 diabetes

Hanlon et al. study the prevalence of frailty and multimorbidity in a cohort of 20,566 UK Biobank participants with type 2 diabetes aged between 40 and 72 years. They observe that, even in this relatively young population, people living with frailty and/or multimorbidity are at increased risk of adverse outcomes including mortality, major adverse cardiovascular events, and hypoglycaemia.

Peter Hanlon
Bhautesh D. Jani
Frances S. Mair
ResearchOpen Access27 Aug 2021
Communications Medicine

Volume: 1, P: 1-9
Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role?

Bhautesh Dinesh Jani
Michael K. Sullivan
Frank M. Sullivan
ResearchOpen Access25 Oct 2023
British Journal of Cancer

Volume: 129, P: 1968-1977
EPOS Primary Care Guidelines: European Position Paper on the Primary Care Diagnosis and Management of Rhinosinusitis and Nasal Polyps 2007 — a summary

Mike Thomas
Barbara Yawn
Wytske Fokkens
Reviews25 Apr 2008
Primary Care Respiratory Journal

Volume: 17, P: 79-89
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709

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