Nature Search

Deep convolutional neural networks to predict cardiovascular risk from computed tomography

Coronary artery calcium is an accurate predictor of cardiovascular events but this information is not routinely quantified. Here the authors show a robust and time-efficient deep learning system to automatically quantify coronary calcium on CT scans and predict cardiovascular events in a large, multicentre study.

Roman Zeleznik
Borek Foldyna
Hugo J. W. L. Aerts
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-9
DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and drives acquisition of totipotency-like features in somatic cells through DMRT1.

Jumpei Taguchi
Hirofumi Shibata
Yasuhiro Yamada
ResearchOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1-18
MYCL-mediated reprogramming expands pancreatic insulin-producing cells

Hirano et al. show that expression of the MYC family member Mycl in adult pancreatic islets can increase proliferation and expand the functional β-cell population, thereby improving glucose control.

Michitada Hirano
Yusei So
Yasuhiro Yamada
Research10 Feb 2022
Nature Metabolism

Volume: 4, P: 254-268
Identification of Macrolide Antibiotic-binding Human_p8 Protein

Tetsuro Morimura
Mio Hashiba
Fumio Sugawara
Research01 May 2008
The Journal of Antibiotics

Volume: 61, P: 291-296
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.

Shingo Komura
Kenji Ito
Yasuhiro Yamada
ResearchOpen Access05 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Detection of non-targeted transgenes by whole-genome resequencing for gene-doping control

Teruaki Tozaki
Aoi Ohnuma
Shun-ichi Nagata
Research07 Aug 2020
Gene Therapy

Volume: 28, P: 199-205
Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice

Manabu Ozawa
Jumpei Taguchi
Masahito Ikawa
ResearchOpen Access13 Dec 2022
Scientific Reports

Volume: 12, P: 1-13
Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

Teruaki Tozaki
Aoi Ohnuma
Shun-ichi Nagata
ResearchOpen Access06 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Effectiveness of a computerized clinical decision support system for prevention of glucocorticoid-induced osteoporosis

Toru Morikawa
Mio Sakuma
Takeshi Morimoto
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14

Search

Deep convolutional neural networks to predict cardiovascular risk from computed tomography

DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

MYCL-mediated reprogramming expands pancreatic insulin-producing cells

Identification of Macrolide Antibiotic-binding Human_p8 Protein

Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Detection of non-targeted transgenes by whole-genome resequencing for gene-doping control

Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice

Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

Effectiveness of a computerized clinical decision support system for prevention of glucocorticoid-induced osteoporosis

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

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