Nature Search

Increased Expression of Angiotensin Converting Enzyme 2 in Conjunction with Reduction of Neointima by Angiotensin II Type 1 Receptor Blockade

Michiya Igase
Katsuhiko Kohara
Carlos M Ferrario
Research01 Mar 2008
Hypertension Research

Volume: 31, P: 553-559
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
Identification of type 2 diabetes loci in 433,540 East Asian individuals

A meta-analysis of genome-wide association study data from 77,418 individuals of East Asian ancestry with type 2 diabetes identifies novel variants associated with increased risk of type 2 diabetes.

Cassandra N. Spracklen
Momoko Horikoshi
Xueling Sim
Research06 May 2020
Nature

Volume: 582, P: 240-245
Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.

Fumihiko Takeuchi
Masato Akiyama
Norihiro Kato
ResearchOpen Access28 Nov 2018
Nature Communications

Volume: 9, P: 1-16
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

Norihiro Kato
Marie Loh
John C Chambers
Research21 Sept 2015
Nature Genetics

Volume: 47, P: 1282-1293
The trans-ancestral genomic architecture of glycemic traits

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Ji Chen
Cassandra N. Spracklen
Cornelia van Duijn
Research31 May 2021
Nature Genetics

Volume: 53, P: 840-860
Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study

Masaki Mogi
Katsuhiko Kohara
Masatsugu Horiuchi
Research09 Mar 2018
Hypertension Research

Volume: 41, P: 326-333
Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension

Yuko Ohta
Kei Kamide
Yuhei Kawano
Research20 Nov 2019
Hypertension Research

Volume: 43, P: 220-226
Interaction between Serotonin 2A Receptor and Endothelin-1 Variants in Association with Hypertension in Japanese

Miyuki Yamamoto
Jing Ji Jin
Jun Nakura
Research01 Apr 2006
Hypertension Research

Volume: 29, P: 227-232
Orthostatic hypertension as a predisposing factor for masked hypertension: the J-SHIPP study

Yasuharu Tabara
Michiya Igase
Tetsuro Miki
Research16 Jun 2016
Hypertension Research

Volume: 39, P: 664-669
Usefulness of the second derivative of the finger photoplethysmogram for assessment of end-organ damage: the J-SHIPP study

Yasuharu Tabara
Michiya Igase
Katsuhiko Kohara
Research25 Feb 2016
Hypertension Research

Volume: 39, P: 552-556
Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study

Haiyan Guo
Yasuharu Tabara
Katsuhiko Kohara
Research23 Oct 2009
Hypertension Research

Volume: 33, P: 32-36
Migraine Is Associated with Enhanced Arterial Stiffness

Tokihisa Nagai
Yasuharu Tabara
Katsuhiko Kohara
Research01 Jul 2007
Hypertension Research

Volume: 30, P: 577-583
Habitual hot water bathing protects cardiovascular function in middle-aged to elderly Japanese subjects

Katsuhiko Kohara
Yasuharu Tabara
Michiya Igase
ResearchOpen Access21 Jun 2018
Scientific Reports

Volume: 8, P: 1-8
Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies

Yasuharu Tabara
Michiya Igase
Fumihiko Matsuda
Research28 Feb 2018
Hypertension Research

Volume: 41, P: 354-362
Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study

Maya Ohara
Katsuhiko Kohara
Michiya Igase
ResearchOpen Access13 Apr 2017
Scientific Reports

Volume: 7, P: 1-10
Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject

Namiko Ochi
Yasuharu Tabara
Katsuhiko Kohara
Research27 Feb 2009
Hypertension Research

Volume: 32, P: 255-260

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