Nature Search

In situ architecture of the human prohibitin complex

Lange, Ratz, et al. investigate the number and distribution of human prohibitin complexes in the mitochondrial inner membrane, uncovering their bell-shaped structure and assembly of alternating PHB1 and PHB2 molecules.

Felix Lange
Michael Ratz
Stefan Jakobs
ResearchOpen Access21 Mar 2025
Nature Cell Biology

Volume: 27, P: 633-640
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

Ratz et al. present an easy-to-use method to barcode progenitor cells, enabling profiling of cell phenotypes and clonal relations using single-cell and spatial transcriptomics, providing an integrated approach for understanding brain architecture.

Michael Ratz
Leonie von Berlin
Jonas Frisén
ResearchOpen Access24 Feb 2022
Nature Neuroscience

Volume: 25, P: 285-294
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

It remains challenging to characterise somatic copy number alterations (SCNAs) in tumors and the surrounding tissues with spatial and single-cell resolution. Here, the authors develop the scCUTseq approach to characterise SCNAs from single cells in multi-region prostate cancer samples and identify pseudo-diploid cells and subclones.

Ning Zhang
Luuk Harbers
Nicola Crosetto
ResearchOpen Access24 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Nanoscopy with more than 100,000 'doughnuts'

Two incoherently superimposed orthogonal standing waves are used to create a pattern of 116,000 'doughnuts' for fast, highly parallelized coordinate-targeted super-resolution microscopy of living cells, with a large field of view.

Andriy Chmyrov
Jan Keller
Stefan W Hell
Research07 Jul 2013
Nature Methods

Volume: 10, P: 737-740
Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy

A super-resolution microscope images live cells in 3D with high speed, large fields of view and minimal photodamage.

Andreas Bodén
Francesca Pennacchietti
Ilaria Testa
Research11 Jan 2021
Nature Biotechnology

Volume: 39, P: 609-618
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Single-cell transcriptome profiling of human embryonic sympathoadrenal tissues identifies developmental transitions and suggests that intra-adrenal sympathoblasts arising from Schwann cell precursors are a potential neuroblastoma cell of origin.

Polina Kameneva
Artem V. Artemov
Igor Adameyko
Research08 Apr 2021
Nature Genetics

Volume: 53, P: 694-706
Enhanced photon collection enables four dimensional fluorescence nanoscopy of living systems

Super-resolution microscopy often suffers from low contrast and slow recording times. Here the authors present an optical implementation which makes the fluorescent proteins’ ON–OFF switching cycles more efficient, enhancing contrast and spatio-temporal resolution in 3D cell and tissue imaging.

Luciano A. Masullo
Andreas Bodén
Ilaria Testa
ResearchOpen Access16 Aug 2018
Nature Communications

Volume: 9, P: 1-9
CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells

Michael Ratz
Ilaria Testa
Stefan Jakobs
ResearchOpen Access20 Apr 2015
Scientific Reports

Volume: 5, P: 1-6
Pooled optical screening in bacteria using chromosomally expressed barcodes

Optical pooled screening of libraries with genomic barcodes has not previously been achieved in bacteria. Here we describe such a method in E. coli and apply it to measure the intracellular maturation time of 84 red fluorescent proteins.

Ruben R. G. Soares
Daniela A. García-Soriano
Johan Elf
ResearchOpen Access03 Jun 2025
Communications Biology

Volume: 8, P: 1-9
Myosin light chain phosphorylation exhibits a gradient across the wall of cerebellar arteries under sustained ex vivo vascular tone

Zhe Sun
Zhaohui Li
Michael A. Hill
ResearchOpen Access17 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
STRT-seq-2i: dual-index 5ʹ single cell and nucleus RNA-seq on an addressable microwell array

Hannah Hochgerner
Peter Lönnerberg
Sten Linnarsson
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
Generating FAIR research data in experimental tribology

Nikolay T. Garabedian
Paul J. Schreiber
Christian Greiner
ResearchOpen Access16 Jun 2022
Scientific Data

Volume: 9, P: 1-11

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