In this review, we proposed a unique concept in which if the mobility of the adsorbed water around the proteins and the polymer is the same, protein adhesion will not occur, improving antithrombogenic properties. On the basis of the above concept, we have established the foundational technique for developing antithrombogenic materials and successfully achieved the world's first practical application of antithrombogenic PSf membrane artificial kidneys. The technique that enables polymer design led by computational science is applicable to various medical and diagnostic devices.
- Yoshiyuki Ueno
- Masaki Fujita
- Masaru Nakada
