Search

Gene expression programs underlying memory are not well understood in Drosophila. Here, authors use mushroom body-specific RNA sequencing to characterize the transcriptional trace of long-term memory and key TFs that may regulate it.

Gene regulatory network architecture and complex dosage effects from paralogue diversification converge to shape phenotypic space, producing the potential for both strongly buffered phenotypes and sudden bursts of phenotypic change.

The earliest known human burial in Africa, that of a young child, is dated to around 78,000 years ago.

The use of antiferromagnetic materials in spintronic devices has been proposed as an attractive alternative to ferromagnets, but only a few suitable materials are known. Here, the authors synthesize a new antiferromagnet (AFM)—tetragonal epitaxial CuMnAs—and show that it is ideal for spintronic applications.

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

Analysis of plastic debris found in surface waters shows that lakes and reservoirs in densely populated and urbanized regions, as well as those with elevated deposition areas, are particularly vulnerable to plastic contamination.

Higgins et al. present an AI tool that uses patient data to personalise treatment for Helicobacter pylori, the leading agent of gastric cancer, demonstrating improved eradication rates over prescribed therapies in retrospective clinical analysis.

Coal is widely used for energy generation, but has not been considered for possible functional materials. Here, the authors report the one-step formation of graphene quantum dots from coal at yields of up to 20%, which is advantageous when compared with their syntheses from sp²-type carbon structures.

In the phase 3 CEPHEUS trial, patients with transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma were treated with subcutaneous daratumumab plus bortezomib, lenalidomide and dexamethasone (D-VRd), which led to a significantly deeper and more durable increase in minimal residual disease responses compared with the control arm of VRd.

The Fermi-LAT Collaboration reports a significant γ-ray detection (5.2σ) from the coronae of radio-quiet active galactic nuclei, revealing compact (~10 gravitational radii) and extended (~2.7 × 10⁶ gravitational radii) corona regions, challenging existing models.

The photocatalytic reforming of plastics into value-added chemicals offers a promising strategy to address environmental challenges while providing significant energy benefits. Here, the authors develop modified carbon nitride with enhanced visible light absorption, effectively anchoring under-coordinated IrN₂O₂ sites to catalyze the oxidation of persistent plastic derivatives.

Large barocaloric effects driven by pressure may lead to environmentally friendly cooling, but they have only been observed in a small number of relatively expensive magnetic materials. Here, the authors show large barocaloric effects near the ferrielectric phase transition in ammonium sulphate.

A genomic, transcriptomic and epigenomic analysis of chronic lymphocytic leukemia identifies genetic drivers and molecular subtypes associated with clinical outcomes.

In vivo detection of cell senescence remains a challenge in aging research. This work introduces a novel fluorogenic probe for β-Gal activity that is excreted in urine, providing a simple diagnosis method to estimate the systemic load of senescent cells during aging and senolytic interventions.

Digenic inheritance of deleterious variants in serine/arginine protein kinase 3 (SRPK3) and titin (TTN) leads to a progressive early onset skeletal muscle myopathy. Zebrafish double mutants exhibit a similar myopathy phenotype accompanied by myofibrillar disorganization.

A species-level phylogenetic analysis of the high-elevation flora of the European Alps reveals that the flora is young and colonist rich. Its assembly was primarily driven by the Pleistocene climatic cycles, rather than ancient orogenic events.

Bidirectional neural interface electronic devices offer therapeutic options. Here, the authors present wafer-scale fabrication of flexible nanoporous graphene-based implantable microelectrode arrays with low impedance and high charge injection for in vivo brain recording and nerve stimulation.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Post-acute COVID-19 condition is difficult to quantify because it includes a range of symptoms that may have other causes. In this study, the authors use primary care data from England and Catalonia, Spain, to estimate the incidence of the condition and identify symptoms that occur more frequently following infection than in uninfected controls.

Data on marine litter are scattered. Harmonizing worldwide aquatic litter inventories, this study finds global litter dominated by plastics from take-out food, followed by fishing, with litter being trapped in nearshore areas and land-sourced plastic reaching the open ocean mostly as small fragments.

Space interferometry reveals the hidden and filamentary internal structure of the relativistic jet in 3C 279 at microarcsecond angular resolution. These details challenge previous assumptions on the morphology and radio variability of blazars.

Sustainable end-of-life management strategies for fibre-reinforced plastics are urgently needed from a sustainability perspective. Here the authors develop a solvent-free flash upcycling method, enabling ultrafast and efficient upcycling of fibre-reinforced plastics to fulfil such a need.

Embedding of complex networks in the latent geometry allows for a better understanding of their features. The authors propose a framework for mapping complex networks into high-dimensional hyperbolic space to capture their intrinsic dimensionality, navigability and community structure.

Two small-molecule drugs, risdiplam and branaplam, have been developed for treating spinal muscular atrophy. Here the authors develop quantitative modeling methods for the sequence-specific and concentration-dependent effects of these and other splice-modifying drugs.

The ability to control defects offers the opportunity to design porous materials with desired properties. Here the authors present a strategy to control the generation and growth of periodic missing cluster vacancies in UiO-66 frameworks and analyze their impact on the physical properties and catalytic activity.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

The circadian clock involves daily variations in transcription of a set of core genes. Here, the authors show that oscillations in free calcium concentration, read by calmodulin-like proteins, regulate the clock and are part of this complex mechanism.

By experimentally sampling from sequence spaces larger than 10¹⁰ and using thermodynamic models, the genetic structure of at least some proteins can be well described, indicating that protein genetics is simpler than anticipated.

The internal structure of the neutron has now been probed by highly energetic photons scattering off it. Combined with previous results for protons, these measurements reveal the contributions of quark flavours to the nucleon structure.

Network properties can be modified when they interact with other networks, yet most previous results have focused on equilibrium states exclusively. Here the authors introduce a framework to examine the out-of-equilibrium dynamics of evolutionary processes to mimic real-world interconnected networks.

Single-cell genomic and transcriptomic analyses of longitudinal samples of patients with Richter syndrome reveal the presence and dynamics of clones driving transformation from chronic lymphocytic leukemia years before clinical manifestation

Very-high-energy γ-rays observed ten hours after the prompt emission of the γ-ray burst 180720B can be attributed to either an inverse Compton or an extreme synchrotron process.

High atmospheric concentrations of isoprene have been observed in the Southern Ocean. The authors investigate their potential marine sources and show how these emissions impact the modelling of atmospheric processes and composition in remote environments.

Whole-genome sequencing of chronic lymphocytic leukemia from 485 patients identifies putative coding and noncoding drivers of disease. Genomically defined subgroups show distinct clinical and biological characteristics.

Quantum communication schemes rely on cryptographically secure quantum resources to distribute private information. Here, the authors show that graph states—nonlocal states based on networks of qubits—can be exploited to implement quantum secret sharing of quantum and classical information.

Chemically propelled micropumps are wireless fluid flow driving systems with many potential applications. Here, the authors report a self-driven reusable Nafion micropump fueled by different salt cations in a wide range of concentrations that triggers both radial and unidirectional flows, showing efficient water remediation capabilities.

Analysis of a European cohort estimated that 1–2 per 10,000 children, adolescents and young adults are expected to develop a hematological malignancy within 12 years following computed tomography examination.

Mutations in a protein active site can alter function in useful ways, but the active site is sensitive to changes. Here the authors present a general strategy to design combinatorial mutation libraries. Applied to GFP, the authors isolate thousands of fluorescent designs that exhibit large and useful changes in spectral properties.

A method to accelerate the generation of kidney organoids from human pluripotent stem cells cultured in a three-dimensional environment and exposed to inductive stimuli has been developed, with the organoids capable of recapitulating kidney organogenesis.

Winged radio galaxies possess wing features detectable at radio wavelengths, yet the physical interpretation of such extragalactic radio sources remains elusive. Here, the authors report the observation of a downsized Z-shaped radio emission from the Galactic microquasar GRS 1758-258, shedding light on the formation of wings in radio galaxies given its strongly  reminiscent winged morphology.

Electron transport chain (ETC) regulation can have important consequences for cellular bioenergetics. Here, Acín-Pérez et al. show that macrophage ETC regulation by the Fgr kinase can also affect systemic metabolism in the setting of diet-induced obesity.

It remains a challenge to find the structure and the distribution of the constituents of nucleons. Here the authors use a scattering method to get information about the gluons and quarks inside a proton and separate the contribution of Bethe-Heitler from the deeply virtual Compton scattering process.

An integrated resource of (epi)genomic features in annotated chronic lymphocytic leukemia (CLL) primary samples uncovers subgroup-specific regulatory alterations associated with clinical behavior.

Explaining why interactions of metal particles with oxide supports can improve their catalytic performance has proved challenging. The origin and nature of metal–oxide interactions on industrially important platinum–ceria catalysts are now clarified, together with the dependence of the catalytic activity on the structure of the support.

Noise and decoherence are serious problems for scalable quantum computing schemes. Using an all-optical approach, Bell et al.explore the use of four-qubit graph states for encoding quantum information, and show that they can reliably detect and correct errors against loss.