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Pretrained using 335,645 whole-slide images, a foundation model is developed to provide representations for slide- and patient-level tasks. It is capable of performing clinical tasks and generating reports even in data-scarce scenarios, such as rare cancer diagnosis and survival prediction, without requiring further fine-tuning.
In this follow-up study presenting results at 96 weeks, cabotegravir and rilpivirine long-acting therapy remained noninferior to oral therapy, had acceptable safety and tolerability profiles, and resulted in durable virologic suppression, further supporting its consideration for African treatment programs.
In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.
A new study expands the utility of the gold-standard ferret model to assess the risks that are associated with consuming raw milk and cheese contaminated with influenza A virus — marking an important step toward improving risk assessments in public health.
We show that clinically accredited genomic newborn screening can be delivered with short turnaround times, detects many more conditions than standard newborn screening, and is both clinically impactful and highly acceptable to families.
This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.
We found that adults carrying melanocortin 4 receptor (MC4R) mutations had lower levels of low-density lipoprotein cholesterol, lower triglyceride levels and reduced cardiovascular disease risk than adults without mutations, despite severe obesity. We show that brain MC4Rs regulate lipid metabolism in humans, highlighting potential therapeutic approaches for cardiovascular risk reduction.
The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
The first month-by-month analysis of malnutrition in children of preschool age in Gaza reveals the acute impact of aid restrictions and conflict — with the most recent estimates showing more than 50,000 children severely malnourished.
The future of HIV research — and of the USA’s scientific leadership — depends on bold, sustained action in defense of discovery, investment, and innovation.
