News & Comment

Between genotype and phenotype

Editorial01 Dec 2006
Telling evolutionary tales

Andrew J Roger
Book Review01 Dec 2006
Contribution of consanguinuity to polygenic and multifactorial diseases

Igor Rudan
Harry Campbell
Alan F Wright
Correspondence01 Nov 2006
Human genetics in the Crescent City

Editorial01 Nov 2006
Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome

Quan-Hu Sheng
Lian-Shui Wang
Jia-Rui Wu
Correspondence01 Nov 2006
Research highlights

Research Highlights01 Oct 2006
Many hypotheses but no replication for the association between PDE4D and stroke

Jonathan Rosand
Nick Bayley
Paul I W de Bakker
Correspondence01 Oct 2006
Minimum compliance for a microarray experiment?

Results generated with the use of microarrays should be properly described and deposited in one of the public databases prior to review. We examine the last two years of the journal's publications in an attempt to ensure that community standards for data deposition are met.

Editorial01 Oct 2006
A weed for one year

Alan Packer
Book Review01 Oct 2006
Reply to “Many hypotheses but no replication for the association between PDE4D and stroke”

Jeffrey R Gulcher
Augustine Kong
Kari Stefansson
Correspondence01 Oct 2006
The genetics of health

Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.

Joseph H Nadeau
Eric J Topol
Commentary01 Oct 2006
Genetic testing: care, consent and liability

Neil F Sharpe
Correspondence01 Sept 2006
Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex

Keping Hu
Xinsheng Nan
Weidong Wang
Correspondence01 Sept 2006
The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia

Adrian Gherman
Erica E Davis
Nicholas Katsanis
Correspondence01 Sept 2006
Structural variants deconstruct the genome

Common genomic structural variants predispose to deleterious de novo genomic rearrangements. Understanding how they do so will require population studies across the continuum of genomic variation and ethical discussion of the nature and uses of human variation.

Editorial01 Sept 2006
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

Bruno Galy
Sabine M Hölter
Matthias W Hentze
Correspondence01 Sept 2006
The magnum opus of a tough scientist

Nori Satoh
Book Review01 Sept 2006
Reply to “Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse”

Manik C Ghosh
Hayden Ollivierre-Wilson
Tracey A Rouault
Correspondence01 Sept 2006
Research highlights

Research Highlights01 Sept 2006
Reply to “Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex”

KN Harikrishnan
Sharmistha Pal
Assam El-Osta
Correspondence01 Sept 2006