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  • NotifAI-OS (notification artificial intelligence for opportunistic screening) is a conceptual deep learning-based framework that performs automated multi-target analysis of computed tomography examinations through quantitative tissue density and volumetric measurements to enable comprehensive disease screening during routine computed tomography examinations.

    • Rohit Reddy
    • Perry J. Pickhardt
    • Pranav Rajpurkar
    Comment
  • Engineer and scientist who contributed to the manipulation of single DNA molecules using electric fields, single-cell fusion and innovative integrated electronic microfluidics.

    • Luke P. Lee
    • Hiroyuki Fujita
    • Thomas B. Jones
    Obituary
  • We introduce the Nature Biomedical Engineering editorial team, including our new Chief Editor, and consider what is to come as we move into our tenth year of publishing.

    Editorial
  • Medical digital twins hold promises for advancing personalized medicine. With the rapid growth of multi-organ and multi-omics biomedical data, artificial intelligence can drive more holistic and integrated medical digital twins for human ageing and disease.

    • Junhao Wen
    Comment
  • Decentralized yet coordinated networks of specialized artificial intelligence agents, multi-agent systems for healthcare (MASH), that excel in performing tasks in an assistive or autonomous manner within specific clinical and operational domains are likely to become the next paradigm in medical artificial intelligence.

    • Michael Moritz
    • Eric Topol
    • Pranav Rajpurkar
    Comment
  • Antigen design and optimization for broader yet targeted immune stimulation, and targeted antigen delivery, are reshaping vaccine development for infectious diseases and cancer.

    Editorial
  • Advances in base editing and prime editing, coupled with optimized delivery strategies, are enhancing the efficiency, safety and versatility of genome editing for the treatment of a widening range of genetic diseases.

    Editorial
  • Combining neuroimaging with molecular and cellular data reveals how microscale features shape large-scale brain networks.

    • Pep Pàmies
    Research Highlight
  • Cas9-based ribonucleoproteins engineered via directed evolution and encapsulated in optimized lipid nanoparticles improve genome-editing efficacies in the livers and lungs of mice.

    • Filipe V. Almeida
    Research Highlight
  • High-throughput screening led to the identification of artesunate as an antifibrotic agent that targets the glycoprotein myeloid differentiation factor 2 in the infarcted heart.

    • Valeria Caprettini
    Research Highlight
  • Organic nanoprobes facilitate the imaging of small deep-seated tumours in mice via the X-ray-mediated generation of long-lasting luminescence.

    • Jennifer Haskell
    Research Highlight
  • An autologous transplant of islets derived from chemically induced pluripotent stem cells allowed an individual with type 1 diabetes to forgo insulin.

    • Alessandra Griffo
    Research Highlight

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