Articles

A multimodal pretrained transformer uses 154,274 pairs of chest CT scans and their corresponding reports and is applied to diverse clinical tasks with multimodal data.

scTranslator is a large-scale generative model that translates single-cell transcriptomic data to proteomic data and can assess the impact of gene perturbation on protein levels.

This study investigates the role of SMAD2 genetic variants associated with congenital heart disease on renal development using a CRISPR-engineered human induced pluripotent stem cell model on a microphysiological system.

A non-expansive, biodegradable matrix for human blood vessel organoid development enhances vascular reconstruction and promotes neurogenesis in brain regions of mice after ischaemic stroke through controlled internal degradation and structural stability.

A cardiac microphysiological system enables the screening and discovery of lipid nanoparticle−mRNA complexes that diffuse efficiently and results in effective in vivo mRNA delivery to the heart.

A vesicular nanoreactor has increased crosslinks between the constituent polyions for longer blood circulation, and is shown to sensitize solid tumours to asparagine starvation therapy.

Kidney organoids derived from human pluripotent stem cells are infused in a normothermic machine perfusion system to condition explanted porcine kidneys, and the feasibility and viability of their in vivo engraftment are demonstrated.

Cut-seq1, Cut-seq2, DeepCut and CLOVE-seq methods find optimized single-guide RNAs to detect a large number of rare variants in cells.

An iontronic tip-sensing guidewire measures haemodynamic and contact pressure in animal stenosis models and can be integrated with commercial workhorse guidewires.

A recombinant adeno-associated virus system for restricted gene expression in brain endothelial cells enables cerebrovascular disease modelling.

Hybrid gRNAs significantly increase targeted editing in the liver while simultaneously reducing unwanted bystander editing in humanized mouse models.

A computational method designs receptors called T-SenSERs, which have predictable signalling responses to tumour microenvironment soluble factors and can be co-expressed with conventional CARs in T cells to enhance their therapeutic activity.

A modular nanobody-based approach assembles combination vaccines by stably attaching diverse antigens to hepatitis E virus-like particles, preserving native immunogenicity and inducing broad protection against respiratory pathogens.

Following amputation, the neural signals embedded in electromyography recordings from a high-density microelectrode array inserted in a reinnervated muscle can be functionally separated via a mathematical approach without surgically partitioning the distinct neural sources.

Thoracic vertebral segment-specific spinal cord organoids transplanted in a spinal cord injury mouse model can precisely match the transplantation site, establish synaptic connections, enhance in vivo neuroelectric conduction and restore motor function.

CAR-T cells are engineered to express CBD-IL-12 upon STEAP1 recognition to enhance tumour-specific immune responses in mice.

A prime editing-based screen of BCR–ABL1 single-nucleotide variants finds resistance against clinically used tyrosine kinase inhibitors.

A gene-editing-based nanoplatform for knockout of HO-1 in tumours is combined with photodynamic therapy, triggering immunogenic cell death.

A biodegradable implant inserted after tumour removal sustainably releases immune modulators and reprograms tumour-infiltrating myeloid cells toward a pro-inflammatory, antitumour phenotype, offering a promising therapeutic strategy for preventing glioblastoma recurrence.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.