We take a look at how scientific articles have evolved over time and envision possible changes to how research findings are communicated in the age of digital media and artificial intelligence.

This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic biology to control mRNA expression and protein localization.

A summary of CAR T-cell engineering approaches, including functional screening methods, gene editing and delivery advances, and optimization of metabolic fitness.

scTranslator is a large-scale generative model that translates single-cell transcriptomic data to proteomic data and can assess the impact of gene perturbation on protein levels.

This study investigates the role of SMAD2 genetic variants associated with congenital heart disease on renal development using a CRISPR-engineered human induced pluripotent stem cell model on a microphysiological system.

A non-expansive, biodegradable matrix for human blood vessel organoid development enhances vascular reconstruction and promotes neurogenesis in brain regions of mice after ischaemic stroke through controlled internal degradation and structural stability.

A cardiac microphysiological system enables the screening and discovery of lipid nanoparticle−mRNA complexes that diffuse efficiently and results in effective in vivo mRNA delivery to the heart.

A vesicular nanoreactor has increased crosslinks between the constituent polyions for longer blood circulation, and is shown to sensitize solid tumours to asparagine starvation therapy.

Kidney organoids derived from human pluripotent stem cells are infused in a normothermic machine perfusion system to condition explanted porcine kidneys, and the feasibility and viability of their in vivo engraftment are demonstrated.

NotifAI-OS (notification artificial intelligence for opportunistic screening) is a conceptual deep learning-based framework that performs automated multi-target analysis of computed tomography examinations through quantitative tissue density and volumetric measurements to enable comprehensive disease screening during routine computed tomography examinations.

We take a look at how scientific articles have evolved over time and envision possible changes to how research findings are communicated in the age of digital media and artificial intelligence.