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A multipass optical parametric amplifier leverages dispersion-engineered dielectric mirrors to overcome the gain versus bandwidth trade-off and achieve broadband amplification with high gain within a compact device.
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lunapark protein and is modulated by nutrient status.
A method using subtree pruning and regrafting-based tree assessment (SPRTA), which considers evolutionary relationships between lineages, enhances interpretability of phylogenetic analyses such as those of SARS-CoV-2 variants.
Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.
The Fair Human-Centric Image Benchmark (FHIBE, pronounced ‘Feebee’)—an image dataset that implements best practices for consent, privacy, compensation, safety, diversity and utility—can be used responsibly as a fairness evaluation dataset for many human-centric computer vision applications.
High-resolution satellites reveal major uncertainties in methane emissions from global waste sites, highlighting the need to reconcile observed and reported data, with actionable insights to improve estimates and guide targeted mitigation efforts.
Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of individuals with multiple-system atrophy.
PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.
The combination of computational design, laboratory-based screening and biophysical validation enables the de novo generation of variable heavy-chain antibody fragments and antibodies that precisely target chosen disease-related molecules.
Lineage tracing in human tissue samples from gestational weeks 16 to 24 provides insight into lineage relationships between cortical cell types and shows a switch in progenitor output from glutamatergic to GABAergic neurons.
A high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex from embryonic to postnatal development is presented, providing a real-time dynamic molecular map associated with individual cell types and specific developmental events.
Structures of GDP-bound MOR–Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists decrease GDP affinity, promoting GTP exchange, and antagonists increase GDP affinity, dampening activation, thus providing structural and mechanistic insights into G protein activation.
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is conserved across placental mammals and is homologous to Th striatal interneurons in rodents.
An investigation of plant receptor-like kinases identifies regions of these proteins that control whether immune or symbiotic signalling pathways are activated, with minimal changes to specific residues in one of these regions being sufficient to alter signalling specificity.
A previously unsampled deep lineage in central Argentina was discovered that had distinctive genetic drift by 8,500 bp and persisted as the main Native American ancestry component in the region up to the present day.
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.
