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This review applies the allostasis framework to complex diseases, linking chronic stress and allostatic load to drug addiction, immune diseases, and cancer, and highlights multi-omics, iPSC, and organoid technologies as emerging tools to study them.
Motion sickness, a common response to unnatural motion, varies widely among individuals. A review of recent findings highlights the gut’s active role, including its brain-body pathways potentially driving pathophysiology and hinting at a more complex model than previously thought.
This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic potential in metabolism and neuroprotection.
This review explores the genomic diversity, ecology, and functional potential of the bacterial family Endozoicomonadaceae in marine symbioses, highlighting their mutualistic to parasitic spectrum and key gaps to be addressed in future research.
This review summarizes the current progress on linguistic neural decoding from a machine learning perspective, focusing on the extraction and generation of text and speech information from brain activity patterns.
A review summarizes the knowledge about the role of redox homeostasis in the functioning of skin melanocytes and about the possibilities of influencing this status by natural compounds, including vitamins, as well as polyphenols or phytocannabinoids.
This Perspective presents a JEVbased gene therapy platform that delivers and amplifies RNA ASOs within neurons to silence mutant SOD1 in ALS. By combining Trojan horse delivery, neuronspecific replication, and sustained action, this strategy offers a precise and durable framework for CNS-targeted intervention.
This review article discusses the challenges of identifying cancer cells in single-cell data, summarizing current computational solutions as well as underexplored features of malignancy.
This Perspective article proposes a neurodynamical model of intuition as a fast, embodied pathfinding mechanism shaped by evolution. Drawing on the free-energy principle and metastability, it explores how the brain predicts, feels, and acts through dynamic coordination.
ADMSCs offer promise for Type 1 Diabetes therapy due to their immunomodulatory and regenerative properties. This review highlights current findings, clinical relevance, and challenges in translating ADMSC-based treatments into standard care.
This review summarizes how TLR2 and TLR4 mediate physiological and pathological inflammation in reproduction, highlighting their signaling pathways, regulatory mechanisms, and implications for fertility and therapeutic strategies.
Sperm navigate the human Fallopian tube by three distinct processes. While their behavioral mechanisms are known, their molecular basis is gradually being uncovered. These processes can improve in vitro fertilization outcomes in clinical settings.
Palaeo-bioinspiration greatly increases the potential of nature-inspired innovation by incorporating extinct biodiversity, which represents 99.9% of all life on earth.
A review summarizes how progranulin (PGRN) regulates lipid metabolism, dysregulation of which contributes to neurodegeneration. Hence, PGRN represents a promising therapeutic target for restoring lipid homeostasis and mitigating neurodegeneration.
A review summarizes the interplay of the lung microenvironment in metastatic osteosarcoma in human and canines, including immune and resident lung cells, and how this knowledge can inform treatment for both patient populations.
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility.
This perspective highlights spatially restricted coral bleaching as an underexplored ecological phenomenon that offers critical insight into within-colony heterogeneity.
This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs.
This review surveys the core metabolic fluxes employed by sebaceous glands to achieve sebum synthesis and examines the idea that metabolic-driven processes are an important mechanistic component of holocrine secretion.
