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Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organization across kingdoms, underscoring its deep evolutionary origin.
Mitochondrial kDNA and RNA editing in Trypanosoma musculi are associated with a small Complex I, providing insights into mitochondrial metabolism and kDNA dynamics in trypanosomes.
Cross-platform benchmarking of DNA binding specificity models highlights top-performing motif discovery methods and demonstrates the potential of advanced models to capture alternative binding modes of human transcription factors.
Editorial Summary: fMRI, multi-omics, and cellular assays reveal that an intensive mind-body retreat intervention modulates brain network connectivity and plasma signaling pathways linked to neuroplasticity, metabolism, and neurotransmission in healthy adults.
Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions.
Oncostatin M drives epigenetic reprogramming in endothelial cells within clear-cell renal cell carcinoma, promoting tumor progression via KAT6B-mediated acetylation of histone 3 at lysine 14 (H3K14ac).
O-glycosylated strategy paves a new way for the design of peptide-based antagonists, and shed light on the creation of novel therapeutics for amyloid-related disease.
Siderophore-β-lactam conjugates demonstrate species-dependent antibiotic enhancement in Gram-negative bacteria, where both uptake and newly identified PBP binding play critical roles in improving therapeutic efficacy.
Interrupted time series models evaluate the impact of a mosquito control program, providing support for the continued implementation of the program against Cx. pipiens but suggesting the need for complementary strategies against Ae. Albopictus.
Co-occurrence network analysis and differential abundance profiling reveal associations between ruminal viruses and microorganisms directly involved in methane production in dairy cattle.
Distinct cytochrome P450 (CYP) activities associated with specific CYP-redox partnerships show that divergent enzyme activities between human hepatocytes and microsomes may be driven by a mismatch in redox-partner interactions.
A deparaffinization, 3D imaging and quantitative cytoarchitectural phenotyping method for human brains reveals structural differences in patients with Malformation of Cortical Development, advancing analysis of brain pathology at cellular resolution.
Machine learning models for brain sex classification trained on limbic brain structures of adolescents capture developmental processes and the association with mood related mental health in a sex-specific manner.
This study uncovers how contact mutant p53 drives replication over-firing in late S/G2, activates cGAS-STING, and enhances immune checkpoint inhibitor response, offering new insights into therapeutic outcomes of different mutant p53 variants.
nERdy enables accurate ER network reconstruction, revealing the role of Atlastin and Reticulon 4 in promoting tubular matrix formation and junction dynamics, advancing understanding of ER structure regulation.
Accounting for DNA sequence variation improves epigenetic age prediction accuracy in diverse African cohorts and transferability across diverse genetic ancestries.
CellSP is a computational framework for identifying and visualizing subcellular spatial patterns of mRNA. It uncovers gene-cell modules that capture consistent transcript distributions linked to key biological processes in various tissues.
A DsRed transgenic zebrafish develops atrial dilation and valve thickening due to protein aggregation, providing a new model to study valvular heart disease and chronic heart failure.
