By parsing stimulus-responsive sources of astrocytic reactive oxygen species (ROS), Barnett et al. reveal how mitochondrial complex III-derived signals uniquely shape inflammatory responses and astrocyte–neuron crosstalk, linking mitochondrial redox cues to dementia-related neurodegeneration.
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Acknowledgements
F.Y.’s laboratory is supported by NIH/NIA grants RF1AG068175, RF1AG079157 and P01AG026572 (Project 1 and Analytic Core), and the Arizona Alzheimer’s Consortium.
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Pan, H., Yin, F. Mitochondrial ROS sources steer neuroinflammation. Nat Metab (2025). https://doi.org/10.1038/s42255-025-01391-x
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DOI: https://doi.org/10.1038/s42255-025-01391-x