Fig. 5: DM-only eGFR GWAS identified 29 loci, including 27 novel for eGFR in DM. | Communications Biology

Fig. 5: DM-only eGFR GWAS identified 29 loci, including 27 novel for eGFR in DM.

From: Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Fig. 5

Shown are eGFR association P-values in individuals with DM over chromosomal position in combined stage (nDM = 178,691). This DM-specific analysis identified 29 independent eGFR-associated loci in DM. Compared to known DKD loci22,23 (i.e., association with eGFR or CKD in type 1 and/or type 2 DM individuals) and known overall eGFR loci16,20, 2 loci are novel for eGFR overall and novel for DKD (red), 24 are novel for DKD but known for eGFR (orange), and 3 are known DKD and known eGFR loci (purple).

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