Fig. 4: Genetically inferred causal relationships amongst biochemical and cortical traits. | Translational Psychiatry

Fig. 4: Genetically inferred causal relationships amongst biochemical and cortical traits.

From: Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy

Fig. 4

Biochemical-cortical trait pairings with suggestive (PBH < 0.05) or significant (PBonferroni < 0.05) genetic correlation were subjected to latent causal variable (LCV) analysis. Of 35 tested trait pairings associated with regional cortical TH, six exhibited strong evidence (|\(\widehat {GCP}\)| > 0.6, dashed blue vertical line) for a causal relationship, with all involving a biochemical trait acting on the cortical trait. In contrast, no trait pairings associated with the global measures of total SA and mean TH, or regional SA exhibited strong evidence for causality.

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