Fig. 4: Main and joint effects of polygenic risk score (PRS) and post-traumatic stress (PTS) symptoms and subscales at 8 weeks post-trauma on tobacco use in the past 30 days at 6 months post-trauma for all ancestries. | Translational Psychiatry

Fig. 4: Main and joint effects of polygenic risk score (PRS) and post-traumatic stress (PTS) symptoms and subscales at 8 weeks post-trauma on tobacco use in the past 30 days at 6 months post-trauma for all ancestries.

From: Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort

Fig. 4

1PRS-CSx: Polygenic risk score using continuous shrinkage and cross-ancestry methods; generated with summary statistics from the GSCAN database for average cigarette per week and average alcoholic drinks per week. 2IRR: Incidence rate ratio as estimated using the quasipoisson model to relax dispersion parameter assumptions, 95% CI: 95% confidence interval. 3 PTSD: Post-traumatic stress, symptoms were assessed using the post-traumatic stress disorder (PTSD) symptom checklist for the DMS-5 (PCL-5), with relevant subscales also reported (re-experiencing, negative cognition and mood, hyperarousal, and avoidance). Models were also adjusted with 5 principal components for global ancestry, and 5 principal components calculated within the top 3 ancestry groups, determined by >90% of the genetic variance related to ancestry being explained by that component.

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