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Reflections on “mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk”

Molecular Psychiatry volume 30, pages 3321–3322 (2025)Cite this article

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TO THE EDITOR:

We read with great interest the research article titled “Mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk” [1]. The article by Hannah Stocker et al. offers a significant contribution to the field of dementia research by investigating the association between mitochondrial DNA copy number (mtDNAcn) and the risk of developing Alzheimer’s disease (AD) and other forms of dementia. The study leverages the extensive data from the ESTHER cohort, a large-scale, population-based study in Germany, which followed nearly 10,000 participants over 17 years. This long-term perspective and the comprehensive data collection are major strengths, providing a robust foundation for analyzing the complex relationship between mtDNAcn and dementia risk.

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References

  1. Stocker H, Gentiluomo M, Trares K, Beyer L, Stevenson-Hoare J, Rujescu D, et al. Mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk. Mol Psychiatry. 2025;30:131–9.

    Article  CAS  PubMed  Google Scholar 

  2. Hansson O, Blennow K, Zetterberg H, Dage J. Blood biomarkers for Alzheimer’s disease in clinical practice and trials. Nat Aging. 2023;3:506–19.

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Funding

This study was financially supported by the Science and Technology Joint Plan of Liaoning Province (No. 2023JH2/101700213).

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Author notes

  1. These authors contributed equally: Huan Wang, Tianyi Ning.

Authors and Affiliations

  1. College of Acupuncture-Moxibustion and Tuina, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, China

    Huan Wang & Zedong Cheng

  2. College of Laboratory Animal Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, China

    Tianyi Ning & Ziyin Cui

Authors
  1. Huan Wang
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  2. Tianyi Ning
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  3. Ziyin Cui
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  4. Zedong Cheng
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Contributions

Huan Wang: writing original draft, writing review. Tianyi Ning: conceptualisation, writing. Ziyin Cui: funding acquisition, Zedong Cheng: manuscript revising.

Corresponding authors

Correspondence to Ziyin Cui or Zedong Cheng.

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The authors declare no competing interests.

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Wang, H., Ning, T., Cui, Z. et al. Reflections on “mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-risk”. Mol Psychiatry 30, 3321–3322 (2025). https://doi.org/10.1038/s41380-025-02958-6

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  • DOI: https://doi.org/10.1038/s41380-025-02958-6

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