Table 1 Summary of data used for training and testing the LungCNN-Histo and the TMB classification models.
Model | LungCNN-Histo | WS-S1 | LungCNN-TMB and WS-TMB | |||||
|---|---|---|---|---|---|---|---|---|
Dataset name | Histo-Train | Histo-Test | WS-Train | TMB-Train | TMB-Test | |||
Data source | TCGA LUAD | TCGA LUAD | DS2 | TCGA LUAD | TCGA LUAD | TCGA LUAD (unseen sites) | TCGA LUAD (seen sites) | |
Number of cases (number of slides) | 64 (68) | 38 (40) | 50 (50) | 317 (261) | 242 (295) | 84 (84) | 88 (93) | |
Number of tissue source sites | 22 | 20 | N/A | 23 | 21 | 10 | 17 | |
Age range (median) | 38–84 (67.5) | 48–83 (68.5) | 40–70 (56) | 33–87 (67) | 33–87 (67) | 42–84 (64) | 41–88 (69) | |
Pathologic stage | I | 37 | 20 | 35 | 148 | 138 | 40 | 56 |
II | 15 | 11 | 9 | 60 | 54 | 27 | 17 | |
III | 8 | 6 | 6 | 37 | 35 | 10 | 12 | |
IV | 4 | 1 | 0 | 15 | 15 | 7 | 3 | |
N/A | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
Sex | Female | 40 | 17 | 17 | 144 | 134 | 44 | 49 |
Male | 24 | 21 | 33 | 117 | 108 | 40 | 39 | |
Smoking status | Non-smoker | 26 | 17 | 0 | 96 | 89 | 38 | 36 |
Smoker | 30 | 21 | 0 | 157 | 153 | 46 | 52 | |
N/A | 8 | 0 | 50 | 8 | 0 | 0 | 0 | |
TMB status | Low | 47 | 28 | N/A | 182 | 167 | 61 | 59 |
High | 17 | 10 | N/A | 79 | 75 | 23 | 29 | |