Supplementary Figure 12: Regional visualization plots centred on independently-associated variants (A. rs62091461, B. rs12966052, and C. rs12967143) close to the transcription factor 4 (TCF4) and RAB27B genes on chromosome 18 (n = 807,553 individuals). | Nature Neuroscience

Supplementary Figure 12: Regional visualization plots centred on independently-associated variants (A. rs62091461, B. rs12966052, and C. rs12967143) close to the transcription factor 4 (TCF4) and RAB27B genes on chromosome 18 (n = 807,553 individuals).

From: Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Supplementary Figure 12

P-values were obtained from an inverse-variance weighted meta-analysis of summary statistics data from UK Biobank, Psychiatric Genomics Consortium and 23andMe. UK Biobank summary statistics were obtained using a linear association analysis with the results transformed to the logistic scale. Psychiatric Genomics Consortium and 23andMe data were analysed using an additive logistic model. All association analyses were two-sided tests. Recombination rates used in the plots are based on the European 1000 Genomes panel from November 2014.

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