Inhaled particulates from environmental pollutants accumulate in macrophages in lung-associated lymph nodes over years, compromising immune surveillance via direct effects on immune cell function and lymphoid architecture. These findings reveal the importance of improved air quality to preserve immune health against current and emerging pathogens.
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This is a summary of: Ural, B. B. et al. Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes. Nat. Med. https://doi.org/10.1038/s41591-022-02073-x (2022).
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Effect of air pollution on the human immune system. Nat Med 28, 2482–2483 (2022). https://doi.org/10.1038/s41591-022-02093-7
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DOI: https://doi.org/10.1038/s41591-022-02093-7
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