Extended Data Fig. 7: Tumor Immune Microenvironment.

a, Tumors from the patient (n=20) had lower overall immune signature score compared to a large cohort of PD-1 treated melanoma patients (n=121) (MWW nominal two-sided p = 0.036);. b, overall Immune signature scores in tumors biopsied within the first 120 days after immunotherapy initiation decreased after initiation of immune checkpoint blockade (linear regression p = 0.020). c, T cell signature scores in the same tumors decrease after initiation of immune checkpoint blockade (linear regression p = 0.008). d, All immune cell signature scores in the same tumors and their association with time after treatment. Negative coefficients are associated with a decrease in score with time after treatment. Boxplots: box limits indicate the IQR (25th to 75th percentiles), with a center line indicating the median. Whiskers show the value ranges up to 1.5 × IQR above the 75th or below the 25th percentiles, with outliers beyond those ranges shown as individual points.