We introduce a diagnostic biomarker for amyotrophic lateral sclerosis that distinguishes it from similar conditions by examining a combination of plasma proteins. This innovation also offers insights into the underlying mechanisms of the disease, highlighting a compensatory process in skeletal muscle and bioenergetics that seems to start much earlier than previously thought.
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References
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This is a summary of: Chia, R. et al. A plasma proteomics-based candidate biomarker panel predictive of amyotrophic lateral sclerosis. Nat. Med. https://doi.org/10.1038/s41591-025-03890-6 (2025).
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Diagnosing ALS: a surprisingly arduous hike lasting 150 years. Nat Med 31, 3266–3267 (2025). https://doi.org/10.1038/s41591-025-03989-w
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DOI: https://doi.org/10.1038/s41591-025-03989-w