Fig. 1: Study overview.
From: Polygenic prediction of body mass index and obesity through the life course and across ancestries
PGSs were constructed using ancestry-specific GWAS summary statistics, using ancestry-specific (PRS-CS) and ancestry-combined (PRS-CSx) approaches. Tuning of the global shrinkage parameter (ϕ) and optimal weights for the linear combination version of PRS-CSx was performed in the UKBB. The best-performing score across multiple ancestries was taken forward to independent validation studies (linear combination version of PRS-CSx with ϕ 1 × 10−2). Population descriptors shown in the figure reflect a combination of self-identified ethnicity and genetic similarity. Created in BioRender: Smit, R. (2025): https://BioRender.com/fglrflj.