Extended Data Fig. 4: Glial fibrillary acidic protein abundance in the DODSR study population.

Glial fibrillary acidic protein (GFAP) normalized protein expression (NPX) in samples from people with multiple sclerosis (MS) compared to healthy controls (HC) in the Department of Defense Serum Repository (DODSR), and in relation to symptomatic onset of the disease. A shows NPX values in pre-symptomatic MS samples, their controls and the p-value for comparison (nominal p from limma models correcting for age and sex). B shows the same comparison using post-onset samples. C shows predicted GFAP NPX evolution over time between pre- and post-onset samples and p-value for interaction term between NPX and duration between samples using linear mixed model accounting for age at pre-onset sample, and sex.