Fig. 1: Meningioma cohort stratified based on molecular classification and the role of EOR.

a,b, CONSORT diagram demonstrating the cohort of meningiomas used in this study, the sequence of analyses and results presented and the respective institutions from where these samples were obtained for our EOR, Simpson grade, and RT analyses (a) and for RT model building (b). c,d, Sankey plot (c) and bar plots (d) showing the relationship of WHO grading with molecular classifications (Molecular Group (MG) for primary analysis and DKFZ methylation subclass to confirm the molecular diagnosis of meningioma). e,f, Kaplan–Meier survival curves showing PFS of meningiomas based on WHO grade (e) and MG (f). g–h, OS of meningiomas used in our study based on classification by WHO grade (g) and MG (h). Inset shows the P values from the pairwise log-rank test between groups with Benjamini–Hochberg correction for multiple comparisons.