Rapidly progressive glomerulonephritis refers to a group of severe autoimmune kidney diseases. Using high-resolution spatial transcriptomics, we identified a common pathway of disease progression and uncovered sequential PDGF and TGFβ activation of parietal epithelial cells as critical drivers of glomerulonephritis. Our study provides valuable insights that could result in disease stage-specific treatment options.
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References
Kurts, C., von Vietinghoff, S., Krebs, C. F. & Panzer, U. Kidney immunology from pathophysiology to clinical translation. Nat. Rev. Immunol. 25, 460–476 (2025). A review that provides an overview of the role of immune cells in different kidney diseases.
Tsokos, G. C. The immunology of systemic lupus erythematosus. Nat. Immunol. 25, 1332–1343 (2024). A review that provides an overview of systemic lupus erythematosus and the underlying immunology.
Shankland, S. J., Smeets, B., Pippin, J. W. & Moeller, M. J. The emergence of the glomerular parietal epithelial cell. Nat. Rev. Nephrol. 10, 158–173 (2014). A review that presents the role of PECs in different glomerular diseases.
Haghverdi, L., Buttner, M., Wolf, F. A., Buettner, F. & Theis, F. J. Diffusion pseudotime robustly reconstructs lineage branching. Nat. Methods 13, 845–848 (2016). This paper presents the diffusion pseudotime method that we used to analyse the trajectory of crescent formation.
Engesser, J. et al. Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis. Nat. Commun. 15, 8220 (2024). This paper used spatial transcriptomics to define inflammatory niches and digital pharmacology to identify therapeutic targets on T cells.
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This is a summary of: Sultana, Z. et al. Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease. Nat. Immunol. https://doi.org/10.1038/s41590-025-02291-8 (2025).
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Glomerular cross-talk in the progression of autoimmune kidney disease. Nat Immunol 26, 1857–1858 (2025). https://doi.org/10.1038/s41590-025-02314-4
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DOI: https://doi.org/10.1038/s41590-025-02314-4