Fig. 1: Common variant association signals for CAD. | Nature Genetics

Fig. 1: Common variant association signals for CAD.

From: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Fig. 1

MAF versus per-allele OR for CAD for common sentinel variant (MAF > 5%) associations reaching genome-wide significance or the 1% FDR threshold in our study. Colored circles indicate genome-wide significant associations (P < 5.0 × 10−8) with sentinel variants that are not correlated (r2 < 0.2) with a previously reported variant (red), genome-wide significant sentinel variants correlated with a previously reported variant (blue), new genome-wide significant sentinels after meta-analysis with Biobank Japan (gold) and associations reaching the 1% FDR threshold (P < 2.52 × 10−5) in our meta-analysis (gray). Two-sided P values are from Z scores from fixed-effect inverse-variance weighted meta-analyses.

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