Fig. 4: PoPS informs the identification of causal genes for CAD. | Nature Genetics

Fig. 4: PoPS informs the identification of causal genes for CAD.

From: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Fig. 4

a, Feature clusters contributing to causal gene prioritization. Rank-order plot of 2,852 feature clusters (arising from 19,091 distinct features) contributing to the prioritization of likely causal genes for CAD by PoPS. Similarity-based cluster labels are provided for several top clusters. b, Prioritization of MFGE8 for rs1807214. Regional association plot at chromosome 15 demonstrates the prioritization of MFGE8 as the likely causal gene for rs1807214, which lies in an intergenic region of chromosome 15. Genes in the region are plotted by their chromosomal position (x axis) and PoPS (y axis).

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