Extended Data Fig. 6: Scatter plot of SDS p-value bins against mean tSDS (of the bin) using the within-sibship height meta-analysis GWAS data. | Nature Genetics

Extended Data Fig. 6: Scatter plot of SDS p-value bins against mean tSDS (of the bin) using the within-sibship height meta-analysis GWAS data.

From: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Extended Data Fig. 6

In Extended Data Figure 6 each data point is the mean tSDS (SDS alligned with height increasing allele) in a set of 1000 genetic variants. Genetic variants were ordered by height P-value (from within-sibship meta-analysis GWAS data) and divided into bins. The plot illustrates evidence of a correlation between decreasing height P-value and higher mean tSDS suggestive of polygenic adaptation on height increasing alleles. The within-sibship European GWAS meta-analysis data (n = 149,174 individuals) were used for this analysis.

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