Extended Data Fig. 6: Correlation between imputed gene expression and measured plasma protein levels in ARIC EA samples. | Nature Genetics

Extended Data Fig. 6: Correlation between imputed gene expression and measured plasma protein levels in ARIC EA samples.

From: Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Extended Data Fig. 6

Measured plasma protein levels are pre-processed by inverse-rank normalization and adjusted for covariates and 90 PEER factors. Gene expression imputation models for TWAS analyses across all tissues are built based on GTEx V7 datasets (see Supplementary Table 13 for available sample sizes). The imputation models for plasma proteins are built based n=7,213 EA individuals in the ARIC study. In boxplots, the boxes are drawn from first and third quartiles, with the median at the center, and the whiskers extending to 1.5 times the interquartile range from the box boundaries. Figure is truncated in the y-axis at correlation= −0.15 and 0.45 for better display.

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