Extended Data Fig. 4: Comparison of association P-values at lead SNVs at T2D loci between multi-ancestry meta-regression (MR-MEGA), fixed-effects meta-analysis and random-effects (RE2) meta-analysis of up to 180,834 cases and 1,159,055 controls. | Nature Genetics

Extended Data Fig. 4: Comparison of association P-values at lead SNVs at T2D loci between multi-ancestry meta-regression (MR-MEGA), fixed-effects meta-analysis and random-effects (RE2) meta-analysis of up to 180,834 cases and 1,159,055 controls.

From: Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Extended Data Fig. 4

Each point corresponds to an SNV, plotted according to P-values (on a -log10 scale) from MR-MEGA on the x-axis and fixed- or random-effects meta-analysis on the y-axis. SNVs below the y = x line demonstrate stronger association with MR-MEGA. The lead SNV at the TCF7L2 locus has been removed to improve clarity of presentation.

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