Fig. 1: Manhattan plot of cross-ancestry meta-analysis. | Nature Genetics

Fig. 1: Manhattan plot of cross-ancestry meta-analysis.

From: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Fig. 1

Genome-wide association statistics obtained by IVW meta-analysis of the stratified SAIGE logistic mixed model regression. The y axis corresponds to two-tailed −log10 (Pvalues); the x axis corresponds to genomic coordinates (GRCh37). The horizontal dashed line reflects the threshold for calling genome-wide significant SNPs (P = 5 × 10−8). Color coding and gene labels reflect those prioritized by the gene-prioritization analysis. Labels in bold indicate genes with known highly pathogenic mutations for ALS. SAIGE = Scalable and Accurate Implementation of Generalized mixed model software package.

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