Fig. 4: Relationship between MAF and effect sizes. | Nature Genetics

Fig. 4: Relationship between MAF and effect sizes.

From: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Fig. 4

Each point represents one of the 447 independent genome-wide significant variants identified in our mJAM multiancestry GWAS joint meta-analysis (n = 392,522). The estimated variant effect sizes are expressed in ln(PSA) per minor allele. The curves indicate the hypothetical detectable variant effect sizes for a given MAF, assuming statistical power of 80% and α = 5 × 10−8 (genome-wide significant), and assuming that the sample size of each of our populations is as follows: 297,166 EUR, 61,745 AFR, 6,967 ASN and 26,644 HIS/LAT. Effects are from a meta-analysis of GWAS performed using linear regression.

Back to article page