Extended Data Fig. 6: Examples of genomic alterations that potentially affect CTCF-CTCF chromatin folding loops.
From: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
a-b, Potentially affected insulated neighborhoods a, in esophageal, gastric and colon adenocarcinoma samples near to the CLCN4 gene and b, in liver-HCC and breast cancers near to BCL6 gene. Black boxes show TAD boundaries, arcs represent CTCF ChIA-PET loops observed in three different cell types (gray). CTCF ChIP-Seq (from NHEK cell line) signal is represented by purple histogram. Red vertical bars depict deletions in individual samples.