Extended Data Fig. 4: Further investigation of histology-specific features of boundary-affecting structural variations.
From: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
a, Distribution of average long-range (length of SV>2 Mb) structural variations (deletion (dashed-red), inversion (dashed-cyan), duplication (dashed-green) and complex rearrangements (dashed-orange)) per sample for each cancer histology subtypes. b, A recurrently deleted TAD boundary in colorectal adenocarcinoma samples near to the RBFOX1 gene. Colored bars on top depict chromosomal locations of the boundaries. Columns of the heatmap are TAD boundaries and rows represent each colorectal adenocarcinoma sample. TAD boundaries affected by BA-deletions are colored in red. Schematic below show the deleted boundary (red box) near to the RBFOX1 gene. c, Distributions of total SV burden (deletions: red, inversions: cyan, duplications: green, complex: orange) across chromosomes. d, Distributions of boundary affecting SVs across chromosomes.