Fig. 1: TAD boundaries are affected by different types of somatic SVs in cancer genomes.
From: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
a, Profiles of TAD signals, active transcription start sites (TSS), CTCF peaks, DNase I hypersensitivity and heterochromatic states around common TAD boundaries. Dashed lines represent enrichment levels for the shuffled boundaries. b, The percentage of short-range SVs (length ≤ 2 Mb) across TADs (shaded) and within TADs (solid) for different SV types. SVs that occur across TADs are referred to as BA-SVs. c, Observed (arrows) and expected distribution (histograms) of BA-SVs. The expected distribution is based on randomly shuffled boundary data. d, Number of affected boundaries (x axis) per short-range SV length cut-off (y axis). The size of the circles indicates the portion of BA-SVs that affect the specific number of boundaries for each length scale. BA-deletion, BA-inversions, BA-duplications and BA-complex rearrangements are shown in red, cyan, green and orange, respectively. e, Histograms represent the length distribution of somatic and germline deletions in the PCAWG cohort within the 75–250 kb range. Pie charts show the percentage of deletions across TADs (shaded) (4.1% for somatic and less than 0.1% for germline events) and within TADs (solid).