Fig. 3: In vivo suppression of DOCK2 in a Syrian hamster model of SARS-CoV-2 infection.
From: DOCK2 is involved in the host genetics and biology of severe COVID-19
a, Changes in body weight of hamsters infected with SARS-CoV-2. b, Representative images of lungs collected after euthanizing the hamsters at 11 dpi. c, Lung weight changes after infection. The number of samples (n) is indicated. d, Representative lung histopathology and immunohistochemistry of the infected hamsters at 6 dpi. Outlined areas are expanded to the right of each image. Right, lung tissue was stained with the anti-CD68 mouse monoclonal antibody to highlight alveolar macrophages. e, SARS-CoV-2 viral loads in the organs of the infected hamsters at 3 and 6 dpi. f, Lung cytokine expression assays of the infected animals. Ip-10 is also known as CXCL10. In (a) and (c), the error bars represent standard error of the mean, and P values were determined with two-sided Welch’s t-test; *P < 0.05; **P < 0.01; ***P < 0.001. In (e) and (f), boxes denote the IQR, and the median is shown as horizontal bars. Whiskers extend to 1.5 times the IQR, and all animals are shown as individual points. P values were determined with two-sided Wilcoxon rank sum test.