Fig. 1: GWAS in a Japanese population stratified by COVID-19 severity and age.
From: DOCK2 is involved in the host genetics and biology of severe COVID-19
a, Forest plots of the risk of COVID-19-associated variants in a Japanese population. Error bars indicate the 95% confidence interval. b, Manhattan plot of the GWAS on severe COVID-19 in young patients (those less than 65 years of age) (440 cases and 2,377 controls). Uncorrected P values from the GWAS analysis are shown. The dotted line represents the genome-wide significance threshold of P < 5.0 × 10−8. Manhattan and quantile–quantile plots of all GWAS results are presented in Extended Data Fig. 2. MT, mitochondrial. c, Regional association plot at the DOCK2 locus. Dots represent SNPs coloured according to linkage disequilibrium (r2) with the lead SNP of rs60200309. FAM196B is also known as INSYN2B. d, Allele frequency spectra of the rs60200309-A allele in the 1000 Genomes Project Phase3v5 database.